Dermatol. praxi. 2007;1(4):147-150

Léčba kůže a sliznice při infekci virem herpes simplex

MUDr. Radek Litvik¹, MUDr. Yvetta Vantuchová²

¹ Kožní oddělení Fakultní nemocnice Ostrava

² Kožní oddělení FN Ostrava

Herpes simplex virus (HSV) is a double – stranded linear DNA member of the human herpesvirus group, which has the ability to establish latency in sensory nerve ganglia. Primary infection results from direct exposure to active skin lesions or secretions of an infected individual. After inoculation and minimal local replication, herpes simplex virus reaches, the neuronal cells of sensory nerve ganglia throuhg the sensitive nerve fibres without any primary clinical manifestation or, after replication in the ganglia, may progress through sensitive fibres to outbreak as mucocutaneous manifestation. The latent state may persist from months or years and then the herpes simplex virus may be reactivated by stimuli such as ultraviolet irradiation, tissue injury, stress, and menstruation.

Keywords: herpes simplex virus, primary infection, recurrent infection, antiviral therapy

Published: February 1, 2008  Show citation