Dermatol. praxi. 2008;2(1):23-25

Merkel Cell Carcinoma

MUDr. Yvetta Vantuchová Ph.D
Kožní oddělení FN Ostrava

Merkel Cell Carcinoma (MCC) is a neuroendocrine skin cancer with the agressive biological behaviour. Incidence of MCC is 0,4 per 100 000 and five years survival rate is 65 %. The most common sites of primary lesion are head, neck and extremities. Optimal treatment of patiens with MCC is radical surgery, dissection of regional lymphatic nodes with sentinel lymph node detection and adjuvant locoregional radiotherapy if risk prognostic factors are present. The role of chemotherapy is controversial and should be considered in patients with advanced disease.

Keywords: Merkel Cell Carcinoma, epidemiology, diagnostics, therapy and prognosis

Published: April 1, 2008  Show citation

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Vantuchová Y. Merkel Cell Carcinoma. Dermatol. praxi. 2008;2(1):23-25.
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    References

    1. Akhtar S, Oza K, Wright J. Merkel cell carcinoma: report of 10 cases and review of the literature. J Am Acad Dermatol 2000; 43: 755-767. Go to original source... Go to PubMed...
    2. Asioli S, Righi A, Volante M, Eusebi V, Bussolati G. p63 expression as a new prognostic marker in Merkel cell carcinoma. Cancer 2007; 110 (3): 640-647. Go to original source... Go to PubMed...
    3. Bischof M, van Kampen M, Huber P, Wannenmacher M. Merkel cell carcinoma: the role of radiation therapy in general management. Strahlenther Onkol 1999; 175: 611-615. Go to original source... Go to PubMed...
    4. Boyle F, Pendlebury S, Bell D. Further insights into the natural history and management of primary cutaneous neuroendocrine (Merkel cell) carcinoma. Int J Radiat Oncol Biol Phys 1995; 31: 315-323. Go to original source... Go to PubMed...
    5. Brenner B, Sulkes A, Rakowsky E et al. Second neoplasms in patients with Merkel cell carcinoma. Cancer 2001; 91: 1358-1362. Go to original source...
    6. Clark JR, Veness MJ, Gilbert R, O´Brien CJ, Gullane PJ. Merkel cell carcinoma of the head and neck: is adjuvant radiotherapy necessary? Head Neck 2007; 29 (3): 249-257. Go to original source... Go to PubMed...
    7. De Wolf-Peeters C, Marien K, Mebis J, Desmet V. A cutaneous APUDoma or Merkel cell tumor? A morphologically recognizable tumor with a biological and histological malignant aspect in contrast with its clinical behavior. Cancer 1980; 46: 1810-1816. Go to original source...
    8. Eng TY, Boersma MG, Fuller CD, Cavanaugh SX et al. Treatment of Merkel cell carcinoma. Am J Clin Oncol 2004; 27 (5): 510-515. Go to original source... Go to PubMed...
    9. Fenig E, Brenner B, Njuguna E, Katz A et al. Oral etoposide for Merkel cell carcinoma in patients previously treated with intravenous etoposide. Am J Clin Oncol 2000; 23: 65-67. Go to original source... Go to PubMed...
    10. Garneski KM, Nghiem P. Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapy. J Am Acad Dermatol 2007; 57 (1): 166-169. Go to original source... Go to PubMed...
    11. Goepfert H, Remmler D, Silva E, Wheeler B. Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck. Arch Otolaryngol 1984; 110: 707-712. Go to original source... Go to PubMed...
    12. Gould VE, Moll R, Moll I, Lee I, Franke WW. Biology of disease: neuroendocrine (Merkel) cells of the skin: hyperplasies, dysplasias and neoplasms. Lab Invest 1985; 52: 334-353.
    13. Hartschuh W. The Merkel cell. In: Bereiter-Hahn J, Matoltsy AG, Richards KS Biology of the integument, Vol 2 Vertebrates. Springer, Berlin Heidelberg New York Tokyo 1986; 605-620. Go to original source...
    14. Hartschuh W (1997) Das Merkelzellkarzinom. In: Garbe C, Dummer R, Kaufmann R (Hrsg) Dermatologische Onkologie. Springer, Berlin Heidelberg New york Tokyo 1997; 489-498. Go to original source...
    15. Hauschild A, Garbe C, Rademacher D, Christophers E (1997) Der Merkel-Zell-Tumor der Haut. Dtsch Med Wochenschr 1997; 122: 753-756. Go to original source... Go to PubMed...
    16. Helmbold P, Schröter S, Holzhausen HJ, Hartschuh W, Marsch WC. Merkel cell carcinoma: a diagnostic and therapeutic challenge. Chirurg 2001; 72: 396-401. Go to original source... Go to PubMed...
    17. Helmbold P, Schröter S, Holzhausen HJ, Dunst J. Merkel-Zell-Karzinom. Hautarzt 2002; 53: 652-658. Go to original source... Go to PubMed...
    18. Hill AD, Brady MS, Coit DG. Intraoperative lymphatic mapping and sentinel lymph node biopsy for Merkel cell carcinoma. Br J Surg 1999; 86: 518-521. Go to original source... Go to PubMed...
    19. Kau RJ, Wagner-Manslau C, Saumweber D, Arnold W. Nachweis von Somatostatinrezeptoren in Tumoren des Kopf-Hals-Bereiches und ihre klinische Bedeutung. Laryngorhinootologie 1994; 73: 21-26. Go to original source... Go to PubMed...
    20. Medina-Franco H, Urist MM, Fiveash J et al. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol 2001; 8: 204-208. Go to original source... Go to PubMed...
    21. MeeuwissenJ, Bourne R, Kearsley J. The importance of postoperative radiation therapy in the treatment of Merkel cell carcinoma. Int J Radiat Oncol Biol Phys 1995; 31: 325-331. Go to original source... Go to PubMed...
    22. Miller RW, Rabkin CS. Merkel cell carcinoma and melanoma: etiological similarities and differences. Cancer Epidemiol Biomarkers Prev 1999; 8: 153.
    23. Mott RT, Smoller BR, Morgan MB. Merkel cell carcinoma: a clinicopathologic study with prognostic implications. J Cutan Pathol 2004; 31 (3): 217-223. Go to original source... Go to PubMed...
    24. Pilotti S, Rilke F, Lombardi L. Neuroendocrine (Merkel cell) carcinoma of the skin. Am J Surg Pathol 1982; 6: 243-254. Go to original source... Go to PubMed...
    25. Raaf JH, Urmacher C, Knapper WK, Shin MH, Cheng EWK. Trabecullar (merkel cell) carcinoma of the skin. Treatment of primary, reccurent, and metastatic disease. Cancer 1986; 57: 178-182. Go to original source...
    26. Shaw JHF, Rumball E. Merkel cell tumour: clinical behaviour and treatment. Br J Surg 1991; 78: 138-142. Go to original source... Go to PubMed...
    27. Snow SN, Larson PO, Hardy S, Bentz M, Madjar D et al. Merkel cell carcinoma of the skin and mucosa: report of 12 cutaneous cases with 2 cases arising from the nasal musosa. Dermatol Surg 2001; 27 (2): 165-170. Go to original source... Go to PubMed...
    28. Tang CK, Toker C. Trabecular carcinoma of the skin. An ultrastructural study. Cancer 1978; 42: 2311-2321. Go to original source...
    29. Toker C. Trabecular carcinoma of the skin. Arch Dermatol 1972; 105: 107-110. Go to original source... Go to PubMed...
    30. Voog E, Biron P, Martin JP, Blay JY. Chemotherapy for patients with locally advanced od metastatic Merkel cell carcinoma. Cancer 1999; 85: 2589-2595. Go to original source...
    31. Wiesser H, Hartschuh W, Greiner A, Bischof M, Enk A, Helmbold P. Merkel cell carcinoma-clinically often misjudged. Dtsch Med Wochenschr 2007; 132 (30): 1581-1586. Go to original source... Go to PubMed...
    32. Yiengpruksawan A, Coit D, Thaler H, Urmacher C et al. Merkell cell carcinoma. Prognosis and management. Arch Surg 1991; 126: 1514-1519. Go to original source... Go to PubMed...

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