Dermatol. praxi. 2010;4(4):217-220

Surgical treatment of vitiligo of non-cultivated autologous melanocytes transplantation - our experience

MUDr.Evžen Trupar¹, prof.MUDr.Pavel Brychta, CSc.¹, Jana Komárková²

¹ Klinika popálenin a rekonstrukční chirurgie, Fakultní nemocnice Brno

² Tkáňová banka, Fakultní nemocnice Brno

Vitiligo belongs to the idiopathic disorders of skin pigmentation. Causal treatment is impossible for now and conservative treatment

is ineffective with most patients. The surgical treatment can be effective with some patients with the history of ineffective conservative



treatment: Many modifications of surgical treatment of vitiligo have apperared during the past few years, from transplantation of

fullthickness skin grafts till transplantation of melanocytes expanded by cultivation. The surgical treatment of vitiligo by grafting of

autologous noncultured melanocytes in fibrin glue which is used as a cell carrier is described in this article. This method is based on

grafting of dermoepidermal graft and its incubation with trypsin. The skin cells suspension which is obtained after the trypsination

is then applied into a mixture with fibrin glue onto depigmented vitiliginous skin previously dermabraded by CO2 laser. We used this

method for treatment at 13 patients with stabile vitiligo, pigmentation was achieved at 5 patients.

Keywords: vitiligo, surgical treatment of vitiligo, transplantation of autologous melanocytes

Published: December 10, 2010  Show citation