Dermatol. praxi. 2014;8(1):6-10

Defects of innate immunity - new pathogenetic aspects of atopic dermatitis

doc.MUDr.Dušan Buchvald, CSc.
Detská dermatovenerologická klinika LFUK a DFNsP, Bratislava

A growing body of evidence suggests that there are a variety of defects in the innate immune system that collectively affect the development

and severity of atopic dermatitis. Genetically based impairment of the epidermal barrier, modifications of pattern recognition

receptors and deficiency of antimicrobial peptides facilitate the entry of allergens and infectious microbes into the skin, where they

encounter immunocompetent cells. The defects of innate immunity not only encourage the evolution of immediate type hypersensitivity

to atopic allergens, but also explain susceptibility of atopic dermatitis patients to pathogens such as Staphylococcus aureus and

herpes simplex virus.

Keywords: atopic dermatitis, innate immunity, epidermal barrier, toll-like receptor, antimicrobial peptide

Published: June 15, 2014  Show citation

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Buchvald D. Defects of innate immunity - new pathogenetic aspects of atopic dermatitis. Dermatol. praxi. 2014;8(1):6-10.
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