Dermatol. praxi. 2018;12(1):40-42 | DOI: 10.36290/der.2018.035

Acute generalised exantematous pustulosis

MUDr. Alena Stumpfová
Kožní oddělení, Masarykova nemocnice Ústí nad Labem

Acute generalised exantematous pustulosis (AGEP) is a rare, severe skin condition characterised by acute onset of sterile pustules.It is triggered mainly by new medication and resolves approximately 2 weeks after its withdrawal. It seems to be a connectionbetween mutation of interleukin 36 antagonist receptor (IL-36Ra) and development of generalised pustular eruption after intakeof new medication in some cases (1). This case reports AGEP caused by solifenacin. It took us longer time to set the right diagnosisas in the beginning the clinical features were not quite clear and, moreover, the onset of the symptoms was slower. Also therewas no specific medication that could trigger the skin disease of AGEP.

Keywords: acute generalised exantematous pustulosis, drug reaction, adverse event, solifenacin

Received: October 8, 2018; Accepted: October 12, 2018; Published: March 22, 2018  Show citation

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Stumpfová A. Acute generalised exantematous pustulosis. Dermatol. praxi. 2018;12(1):40-42. doi: 10.36290/der.2018.035.
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    References

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