Dermatol. praxi. 2018;12(3):117-122 | DOI: 10.36290/der.2018.021

Precancerous conditions and carcinomas in situ in dermatology

doc. MUDr. Hana Jedličková, Ph.D.
Dermatovenerologické oddělení FN Brno

The article provides an overview of precancerous conditions and carcinomas in situ encountered by the dermatologist in commonclinical practice. Obligate precancerous conditions include actinic keratoses, cornu cutaneum, arsenic and tar keratoses, leukoplakia,and some HPV-induced lesions. Carcinomas in situ include Bowen’s disease and erythroplasia of Queyrat. Also describedare pigmentation manifestations and special entities, such as Paget’s disease and keratoacanthoma. Facultative precancerousconditions include some chronic inflammatory diseases or genetically determined conditions, such as chronic wounds, mucosallichen planus, lichen sclerosus et atrophicus, porokeratosis, organoid naevi, and others.

Keywords: precancerous condition, carcinoma in situ, actinic keratosis, Bowen’s disease, Paget’s disease, HPV

Published: October 10, 2018  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Jedličková H. Precancerous conditions and carcinomas in situ in dermatology. Dermatol. praxi. 2018;12(3):117-122. doi: 10.36290/der.2018.021.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Frost CA, Green AC. Epidemiology of solar keratoses. Br J Dermatol. 1994; 131(4): 455-464. Go to original source... Go to PubMed...
    2. Jenni D, Hofbauer GFL. Keratinocyte cancer and its precursors in organ transplant patients. Curr Probl Dermatol. 2015; 46: 49-57. Go to original source... Go to PubMed...
    3. Weedon D, et al. Epidermal dysplasias. In: Weedons Skin Pathology, 3. vydání, Churchill Livingstone Elsevier 2010: 676-679.
    4. Weedon D, et al. Intraepidermal carcinomas. In: Weedons Skin Pathology, 3. vydání, Churchill Livingstone Elsevier 2010: 679.
    5. Roelofzen JH, Aben KK, Oldenhof UT, Coenraads PJ, Alkemade HA, van de Kerkhof PC, van der Valk PG, Kiemeney LA. No increased risk of cancer after coal tar treatment in patients with psoriasis or eczema. J Invest Dermatol. 2010; 130(4): 953-961. Go to original source... Go to PubMed...
    6. Šternberský J. Karcinogenita yperitu. Dermatolog. Praxi. 2007; 2: 90-92.
    7. Weedon D, et al. Intraepidermal carcinomas. In: Weedons Skin Pathology, 3. vydání, Churchill Livingstone Elsevier 2010: 679-682.
    8. von Krogh G, Horenblas S. Diagnosis and clinical presentation of premalignant lesions of the penis. Scand J Urol Nephrol Suppl. 2000; (205): 201-214. Go to original source... Go to PubMed...
    9. Scully C. Leukoplakia. In: Oral and Maxillofacial Medicine The Basis of Diagnosis and Treatment. (3. vydání) Churchill Livingstone 2013: 186-191. Go to original source...
    10. Weedon D, et al. Keratoakanthoma. In: Weedons Skin Pathology, 3. vydání, Churchill Livingstone Elsevier 2010: 702-708.
    11. Weedon D, et al. Extramammary Paget disease. In: Weedons Skin Pathology, 3. vydání, Churchill Livingstone Elsevier 2010: 788-790.
    12. van der Putte SC. Clear cells of Toker in the developing anogenital region of male and female fetuses. Am J Dermatopathol. 2011; 33: 811-818. Go to original source... Go to PubMed...
    13. Basarab T, Millard TP, McGregor JM, Barker JN. Atypical pigmented lesions following extensive PUVA therapy. Clin Exp Dermatol. 2000; 25: 135-137. Go to original source... Go to PubMed...
    14. Roncati L, Piscioli F, Pusiol T. SAMPUS, MELTUMP a THIMUMP - diagnostické kategorie charakterizované nejistým biologickým chováním. Klin Onkol. 2017; 30: 221-223. Go to original source... Go to PubMed...
    15. Bazaliński D, Przybek-Mita J, Barańska B, Więch P. Marjolin's ulcer in chronic wounds - review of available literature. Contemporary Oncology. 2017; 21: 197-202. Go to original source... Go to PubMed...
    16. Cho RJ, Alexandrov LB, den Breems NY, Atanasova VS, Farshchian M, Purdom E, Nguyen TN, Coarfa C, Rajapakshe K, Prisco M, Sahu J, Tassone P, Greenawalt EJ, Collisson EA, Wu W, Yao H, Su X, Guttmann-Gruber C, Hofbauer JP, Hashmi R, Fuentes I, Benz SC, Golovato J, Ehli EA, Davis CM, Davies GE, Covington KR, Murrell DF, Salas-Alanis JC, Palisson F, Bruckner AL, Robinson W, Has C, Bruckner-Tuderman L, Titeux M, Jonkman MF, Rashidghamat E, Lwin SM, Mellerio JE, McGrath JA, Bauer JW, Hovnanian A, Tsai KY, South AP. APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa. Sci Transl Med. 2018; 22: 10(455) eaas9668. Go to original source... Go to PubMed...
    17. de Jong SJ, Imahorn E, Itin P, Uitto J, Orth G, Jouanguy E, Casanova JL, Burger B. Epidermodysplasia Verruciformis: Inborn Errors of Immunity to Human Beta-Papillomaviruses. Front Microbiol. 2018; 9: 1222. Go to original source... Go to PubMed...
    18. Groesser L, Herschberger E, Ruetten A, Ruivenkamp C, Lopriore E, Zutt M, Langmann T, Singer S, Klingseisen L, Schneider-Brachert W, Toll A, Real FX, Landthaler M, Hafner C. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Nature Genetics. 2012; 44(7): 783-787. Go to original source... Go to PubMed...
    19. Pekarek B, Buck S, Osher L. A Comprehensive Review on Marjolin's Ulcers: Diagnosis and Treatment. J Am Col Cert Wound Spec. 2011; 3: 60-64. Go to original source... Go to PubMed...
    20. Škapa P, Pichlík T, Pluta M, Halaška M, Robová H, Rob L, Tachezy R, Zámečník J. Klasifikace vulvárních prekanceróz pohledem patologa. Actual Gyn. 2014; 6: 26-32.
    21. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, Pignatelli P, Lajolo C. Rate of malignant transformation of oral lichen planus: A systematic review. Oral, DiS. 2018 May 8. doi: 10.1111/odi.12885. [Epub ahead of print]. Go to original source... Go to PubMed...
    22. Halonen P, Jakobsson M, Heikinheimo O, Riska A, Gissler M, Pukkala E. Cancer risk of Lichen planus: A cohort study of 13,100 women in Finland. Int J Cancer. 2018; 142(1): 18-22. Go to original source... Go to PubMed...
    23. Paradisi A, Tabolli S, Didona B, Sobrino L, Russo N, Abeni D. Markedly reduced incidence of melanoma and nonmelanoma skin cancer in a nonconcurrent cohort of 10,040 patients with vitiligo. J Am Acad Dermatol. 2014; 71: 1110-1116. Go to original source... Go to PubMed...
    24. Wu W, Wei Q, Sarin KY, Han J. Inverse Relationship between Vitiligo-Related Genes and Skin Cancer Risk. J Invest Dermatol. 2018; 23. pii: S0022-202X(18)31749-4. doi: 10.1016/j.jid.2018. 03. 1511. [Epub ahead of print]. Go to original source... Go to PubMed...
    25. Burd EM. Human Papillomavirus and Cervical Cancer. Clin Microbiol Rev. 2003; 16: 1-17. Go to original source... Go to PubMed...
    26. Olivero C, Lanfredini S, Borgogna C, Gariglio M, Girish K. Patel GK. HPV-Induced Field Cancerisation: Transformation of Adult Tissue Stem Cell Into Cancer Stem Cell Front Microbiol. 2018; 9: 546. Go to original source... Go to PubMed...

    Return to the content


    Dermatology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.