Dermatol. praxi. 2022;16(3):127-129 | DOI: 10.36290/der.2022.024

Melkersson-Rosenthal syndrome in clinical practice

MUDr. Andrea Jelínková, MUDr. Gvantsa Kharaishvili
Klinika chorob kožních a pohlavních LF UP a FN Olomouc
Ústav klinické a molekulární patologie FN Olomouc

Melkersson-Rosenthal syndrome is a rare disorder of unknown etiology characterized by a group of symptoms that most commonly include orofacial edema, facial nerve palsy, and tongue wrinkling. At least two of the above symptoms are necessary for a clinical diagnosis. Corticosteroids are the mainstay of treatment. The following report describes the clinical case of a 51-year-old woman with chronic swelling of the lower lip and the treatment options for Melkersson-Rosenthal syndrome.

Keywords: facial nerve palsy, orofacial granulomatosis, lingua plicata, intralesional corticosteroid application.

Accepted: October 11, 2022; Published: October 17, 2022  Show citation

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Jelínková A, Kharaishvili G. Melkersson-Rosenthal syndrome in clinical practice. Dermatol. praxi. 2022;16(3):127-129. doi: 10.36290/der.2022.024.
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References

  1. Melkersson E. Ett fall av recideverande facial spares. Samband Med Angioneurotisk Odem Hygeia (Stockholm). 1928;90:737-741.
  2. Rosenthal C. Clinisch-erbbiologischer beitrag zur Konstitutions-Pathologie-Gemeknsames Auftreten von (rezidivierender familiarer) Facialislahmung, angioneurotische angioneurotischem und Lingua Plicata in Arthritiomus Famielien. Z Ges Neurol Psychiatr. 1931;131:475. Go to original source...
  3. Değerli Ş, Başman A, Gümüşok M, Kaya M, Alkurt MT. Melkersson-Rosenthal syndrome: a case report. J Istanb Univ Fac Dent. 2017;51(1):42-45.
  4. Tang J-J, Shen X, Xiao J-J, Wang X-P. Retrospective analysis of 69 patients with Melkersson-Rosenthal syndrome in mainland China. Int J Clin Exp Med. 2016;9(2):3901-3908.
  5. Orlando MR, Atkins JS. Melkersson-Rosenthal syndrome. Arch Otolaryngol Head Neck Surg. 1990;116(6):728-729. Go to original source... Go to PubMed...
  6. Saini AG, Sankhyan N, Padmanabh H, Das A, Singhi P. Recurrent facial palsy and electrophysiological findings in oligosymptomatic Melkersson Rosenthal syndrome. Indian J Pediatr. 2016;83(10):1188-1190. Go to original source... Go to PubMed...
  7. Savasta S, Rossi A, Foiadelli T, et al. Melkersson-Rosenthal syndrome in childhood: report of three paediatric cases and a review of the literature. Int J Environ Res Public Health. 2019;16(7):1289. Go to original source... Go to PubMed...
  8. Machovcová A. Diferenciální diagnostika projevů na rtech - část I., Dermatologie pro praxi. 2010;4(1).
  9. Bacci C, Valente M. Successful treatment of cheilitis granulomatosa with intralesional injection of triamcinolone. J Eur Acad Dermatol Venereol. 2010;24(3):363-364. Go to original source... Go to PubMed...
  10. Sumeet R Dhawan, Arushi G Saini, Pratibha D Singhi. Management Strategies of Melkersson-Rosenthal Syndrome: A Review. Int J Gen Med. 2020;13:61-65. Go to original source... Go to PubMed...
  11. Ratzinger G, Sepp N, Vogetseder W, Tilg H. Cheilitis granulomatosa and Melkersson-Rosenthal syndrome: evaluation of gastrointestinal involvement and therapeutic regiment in a series of 14 patients. J. Eur. Acad. Dermatol. Venereol., 2007;21: p. 1065-1070. Go to original source... Go to PubMed...
  12. Ully C, et al. Marathon of eponyms: Melkersson-Rosenthal syndrome. Oral Diseases. 2010;16: p. 708. Go to original source... Go to PubMed...
  13. Barry O, Barry J, Langsan S, Murphy M, Fitzgibbon, J, Lyons JF. Treatment of granulomatous cheilitis with infliximab. Arch. Dematol., 2005;14: p. 1080-1082. Go to original source... Go to PubMed...
  14. Hauer L, Hrušák D, Hostička L, Andrle P, Jambura J, Pošta P, Genčur J. Chirurgická léčba perzistující makrocheilie u pacienta s granulomatózní cheilitidou. LKS. 2017;27(6):140-143.




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