Dermatol. praxi. 2023;17(3):142-145 | DOI: 10.36290/der.2023.027

Alopecia areata - risk factors, prevention possibilites and therapeutical options

MUDr. Barbora Šochmanová, prof. MUDr. Monika Arenbergerová, Ph.D.
Dermatovenerologická klinika 3. LF UK a FNKV, Praha

Alopecia areata is an autoimmune disorder causing an acute patchy hair loss characterised by non-scaring, well-demarcated bald areas of various size. Even though it is not a life threatening disease, it is a condition which has an impact on daily-living of the patient and represent strong psychological distress. Ethiology of alopecia areata is not completely understood, but genetic, environmental and some concomitant comorbidities can play role in pathogenesis. Therapy of AA is difficult and treatment response is individiual. Nevertheless the spectrum of therapeutical possibilities is relatively extensive. In following text is shortly described the etiopathogenesis of AA, prevention, possibilites and therapeutical options.

Keywords: alopecia areata, prevention, disease patophysiology, diagnosis, treatment.

Accepted: October 2, 2023; Published: October 3, 2023  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Šochmanová B, Arenbergerová M. Alopecia areata - risk factors, prevention possibilites and therapeutical options. Dermatol. praxi. 2023;17(3):142-145. doi: 10.36290/der.2023.027.
Download citation

References

  1. Darwin E, Hirt PA, Fertig R, et al. Alopecia Areata: Review of Epidemiology, Clinical Features, Pathogenesis, and New Treatment Options. Int J Trichology. 2018;10(2):51-60. doi: 10.4103/ijt.ijt_99_17. PMID: 29769777; PMCID: PMC5939003. Go to original source... Go to PubMed...
  2. Fricke A, Miteva M. Epidemiology and burden of alopecia areata: a systematic review. Clin Cosmet Investig Dermatol. 2015;8:397-403. Go to original source... Go to PubMed...
  3. King B, Ohyama M, Kwon O, et al. Two Phase 3 Trials of Baricitinib for Alopecia Areata. N Engl J Med. 2022;386(18):1687-1699. doi: 10.1056/NEJMoa2110343. Epub 2022 Mar 26. PMID: 35334197. Go to original source... Go to PubMed...
  4. Yang S, Yang J, Liu JB, et al. The genetic epidemiology of alopecia areata in China. Br J Dermatol. 2004;151(1):16-23. doi: 10.1111/j.1365-2133.2004.05915.x. PMID: 15270868. Go to original source... Go to PubMed...
  5. Verma S, Sinclair R, Das A. Identical Alopecia Areata in Identical Twin Sisters. Int J Trichology. 2020;12(5):247-248. doi: 10.4103/ijt.ijt_120_20. Epub 2020 Nov 3. PMID: 33531751; PMCID: PMC7832170. Go to original source... Go to PubMed...
  6. Holmes S, Harries M, Macbeth AE, et al. Alopecia areata and risk of atopic and autoimmune conditions: population-based cohort study. Clin Exp Dermatol. 2023;48(4):325-331. doi: 10.1093/ced/llac104. PMID: 36689337. Go to original source... Go to PubMed...
  7. Kutlu Ö, Aktaş H, İmren IG, et al. Short-term stress-related increasing cases of alopecia areata during the COVID-19 pandemic. J Dermatolog Treat. 2022;33(2):1177. doi: 10.1080/09546634.2020.1782820. Epub 2020 Jun 19. PMID: 32538230. Go to original source... Go to PubMed...
  8. Scollan ME, Breneman A, Kinariwalla N, et al. Alopecia areata after SARS-CoV-2 vaccination. JAAD Case Rep. 2022;20:1-5. doi: 10.1016/j.jdcr.2021.11.023. Epub 2021 Dec 15. PMID: 34931171; PMCID: PMC8673931. Go to original source... Go to PubMed...
  9. Ohyama, M. What is behind the 'swarm of bees' in alopecia areata. Br J Dermatol. 2018;179:1023-1024. Go to original source... Go to PubMed...
  10. Rajabi F, Drake LA, Senna MM, et al. Alopecia areata: a review of disease pathogenesis. Br J Dermatol. 2018;179(5):1033-1048. doi: 10.1111/bjd.16808. Epub 2018 Sep 9. PMID: 29791718. Go to original source... Go to PubMed...
  11. Ito T, Ito N, Saatoff M, et al. Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J Invest Dermatol. 2008;128(5):1196-1206. doi: 10.1038/sj.jid.5701183. Epub 2007 Dec 27. PMID: 18160967. Go to original source... Go to PubMed...
  12. Fukuyama, M, Ito, T, Ohyama, M. Alopecia areata: Current understanding of the pathophysiology and update on therapeutic approaches, featuring the Japanese Dermatological Association guidelines. J Dermatol. 2022;49:19-36. Go to original source... Go to PubMed...
  13. Olsen EA, Canfield D. SALT II: A new take on the Severity of Alopecia Tool (SALT) for determining percentage scalp hair loss. J Am Acad Dermatol. 2016;75(6):1268-1270. doi: 10.1016/j.jaad.2016.08.042. PMID: 27846957. Go to original source... Go to PubMed...




Dermatology for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.