Dermatol. praxi. 2025;19(4):156-161 | DOI: 10.36290/der.2025.028

Non-melanoma skin cancers: current insights into diagnosis, prevention, and treatment

MUDr. Júlia Bartková, MBA, MPH1, 2, Marie Tormová2, Janusz Rucki2, Sandra Harásková2, Soňa Hrižová3, MUDr. Dušana Selecká4, MUDr. Gabriela Bakšová5
1 Klinika popálenin a plastické chirurgie, Fakultní nemocnice Brno
2 Lékařská fakulta Masarykovy univerzity, Brno
3 Lékařská fakulta Univerzity Komenského, Bratislava, Slovenská republika
4 Kožní oddělení, Nemocnice Šumperk, Šumperk
5 Dermatologický stacionář, Nemocnice Poprad, a. s., Slovenská republika

Non-melanoma skin cancers (NMSC) represent the most frequently diagnosed malignancies in developed countries, with a globally rising incidence. This review article summarizes the main types of NMSC - basal cell carcinoma, squamous cell carcinoma, and Merkel cell carcinoma - with a focus on their epidemiology, risk factors, diagnosis, treatment, and preventive strategies. Particular attention is given to primary and secondary prevention, including current research on chemoprevention agents such as nicotinamide, vitamin D, and celecoxib. The article also discusses the importance of early detection, surgical and non-surgical treatment approaches, and emerging trends in systemic therapy for advanced or recurrent disease. It highlights the growing need for public education and a multidisciplinary approach to improve outcomes in the management and prevention of these common conditions.

Keywords: non-melanoma skin cancer, basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma.

Accepted: December 3, 2025; Published: December 16, 2025  Show citation

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Bartková J, Tormová M, Rucki J, Harásková S, Hrižová S, Selecká D, Bakšová G. Non-melanoma skin cancers: current insights into diagnosis, prevention, and treatment. Dermatol. praxi. 2025;19(4):156-161. doi: 10.36290/der.2025.028.
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