Tabákový průmysl: Na dětech nám záleží!

prof. MUDr. Eva Králíková, CSc.

Dermatol. praxi. 2021;15(3):119  

Hyperpigmentation of the skin and treatment options

MUDr. Lucia Mansfeldová

Dermatol. praxi. 2021;15(3):124-130 | DOI: 10.36290/der.2021.024  

Hyperpigmentation of the skin manifests itself clinically as circumscribed or diffuse darkening of the skin, which is most often caused by a disorder in the production and distribution of melanin. They are more common in people with a dark phototype due to more intense melanin synthesis. In the prevention and treatment of hyperpigmentation, it is important to treat the underlying disease that causes them. At the same time, we symptomatically remove hyperpigmentation with local lightening preparations, chemical peels, cryotherapy, microneedling, plasmatherapy, light or laser therapy. In practice, we often have to choose a combination of individual methods...

Autoimmune blistering diseases - diagnosis, therapy and introducing of biologics into therapeutical approach - part I

doc. MUDr. Miloslav Salavec, CSc.

Dermatol. praxi. 2021;15(3):131-135 | DOI: 10.36290/der.2021.025  

Review article summarizes diagnostic kriteria and therapeutical and supportive care recommendations in management of common epidermal autoimmune bullou diseases including biologic therapy of these clinical entities.

Can rosacea be treated with ivermektin?

MUDr. Dominika Diamantová, Ph.D., doc. MUDr. Jarmila Rulcová, CSc.

Dermatol. praxi. 2021;15(3):136-138 | DOI: 10.36290/der.2021.026  

Recently, the controversial treatment of covid-19 with ivermectin is being discussed in the Czech Republic. Ivermectin is a broad-spectrum antiparasitic. In dermatology we already have six years of experience with local treatment of rosacea with human-registered ivermectin in the cream form, with a positive response from our patients.

Dermatitis perioralis with children

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2021;15(3):139-142 | DOI: 10.36290/der.2021.027  

Perioral dermatitis is a chronic facial dermatosis characterized by small papules and pustules on a red, sometimes scaled skin typically affected area of nasobuccal sulci and a of a chin, with sparing a narrow area round lips. It can be manifested also perinasal and at lateral parts of both eyes. Subjective symptoms include tingling and burning, pruritus is rare. Causative agents at children are most often overusage of tooth-pastes with fluor, various emmolients and local corticoids. For healing an elimination of causative agents and local treatments are necessary. Peroral treatment with children is used only exceptionally. Less severe forms of perioral...

How to treat patients with psoriasis and concurrent multiple sclerosis?

MUDr. Martin Elišák, Ph.D.

Dermatol. praxi. 2021;15(3):144-147 | DOI: 10.36290/der.2021.028  

Multiple sclerosis and psoriasis are autoimmune diseases which share certain immunopathological features. Although the coincidence of the two diseases has not yet been clearly shown to be higher, most meta-analyses suggest so. In the Czech Republic, only one agent is currently approved in the treatment for which efficacy in both diseases has been demonstrated: dimethyl fumarate. Safety and a possible positive effect on both diseases have been demonstrated in secukinumab and ustekinumab which, however, are not approved to treat multiple sclerosis. In the case of moderate or severe psoriasis requiring systemic treatment, it is possible - in treating...

A patient with a severe form of atopic dermatitis, polyvalent allergy and an extreme elevation of IgE

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2021;15(3):155-159 | DOI: 10.36290/der.2021.030  

A case report of a 37 year-old man with a severe form of atopic dermatitis lasting since his age of 22 is presented. The patient was treated with all available systemic treatments: he used cyclosporin A intermittently for 5.5 years, azathioprin for 11 months and methotrexate for 2.3 years. Later, plasmaphereses were carried out for 5 years with a limited results. Subsequently, a biologic therapy with dupilumab led to a very significant improvement first, then to a long- term complete remission lasting for 14 months, till now. The therapy with dupilumab has been very well tolerated. The patient is very satisfied, his quality of life is excellent.

Blastic plasmacytoid dendritic cell neoplasm

MUDr. Michala Kučerová, MUDr. Tomáš Kohoutek

Dermatol. praxi. 2021;15(3):161-163 | DOI: 10.36290/der.2021.031  

Blastic plasmacytoid dendritic cell neoplasm is even more deadly tumor compared to malignant melanoma with a very low 1 year survival rate. Even though this neoplasm belongs into hematologic malignancies first doctor who would see a patient could be dermatologist because of skin lesions.

Early congenital syphilis and importance of STD detection during pregnancy

MUDr. Adriana Kratinová

Dermatol. praxi. 2021;15(3):164-166 | DOI: 10.36290/der.2021.032  

Syphilis congenita recens (early congenital syphilis) is a rare form of syphilis caused by transmission of the spirochete Treponema pallidum from the mother to the fetus after the placenta is developed, e.g. after the 4th month of pregnancy. Approximately 60 to 90 percent of live-born neonates with congenital syphilis are asymptomatic at birth. The presence of signs at birth depends upon the timing of intrauterine infection and treatment. Clinical manifestations ranging from papulopustulosa or vesiculobullous rash, skin and mucous membrane gummas, osteochondritis syphilitica, anemia, hepatitis, and hepatosplenomegaly. Clinical signs can develop up...

Fibroepithelial polyps (acrochordons) - treatment options

MUDr. Kateřina Klauzová, MBA

Dermatol. praxi. 2021;15(3):148-152 | DOI: 10.36290/der.2021.029  

Fibroepithelial polyps are benign tumors arising from connective tissue. They are of mesodermal origin and are usually covered with squamous epithelium and come from the skin, genitourinary tract or lower respiratory tract. On the skin, they occur mainly in the skin folds. They can be isolated or multiple. They are usually no larger than 1-2 millimeters. In rare cases, they can reach enormous dimensions. A giant fibroepithelial polyp 42 centimeters in size has been described in the literature. Although the etiology and factors causing overgrowth are not known, an association with chronic mechanical irritation, obesity, insulin resistance, as well as...

Sweet's syndrome

MUDr. Lubomír Drlík

Dermatol. praxi. 2021;15(3):167-170  

Sweet's syndrome is the febrile neutrophilic dermatosis. It typically presents in patients with fever, neutrophilia, painful tender erythematous papules, nodules and plaques often distributed asymmetrically. Frequent sites include face, neck and upper extremities. Affected sites show a characteristical neutrophilic infiltrate in the dermis. Its etiology remains unclear, but it seems to be mediated by a hypersensitivity reaction in which cytokines, followed by infiltration of neutrophiles, may be involved. Systemic corticosteroids are the first-line of treatment in most cases.