Špatná zpráva; možné reakce pacienta a jejich zvládání (2. část)

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2023;17(1):3  

Care for children with epidermolysis bullosa

Mgr. Petra Šimánková

Dermatol. praxi. 2023;17(1):8-12 | DOI: 10.36290/der.2023.001  

Children with epidermolysis bullosa (EB) are a rare population with high morbidity and mortality. EB has a profound impact on the daily life of the patient and family members, on the child's physical, psychological and mental health, including disruption of social relationships. It is common for EB patients to be cared for by health professionals who are not specialized in this rare disorder. Health professionals educate parents about safety and preventive steps in caring for a child with EB, how to treat the child, how to recognize the characteristics of a wound, how to care for wounds, how to breastfeed and feed the child, etc. Increasing the knowledge...

Gender reassignment and successful biological treatment of severe atopic dermatitis

MUDr. Monika Hudymačová

Dermatol. praxi. 2023;17(1):13-15 | DOI: 10.36290/der.2023.002  

We present the case of a young man suffering from severe atopic dermatitis, who also underwent gender reassignment from female to male. In addition, within the period of exacerbation of AD, the clinical picture of erythroderma with generalized lymphadenopathy mimics hemato-oncological disease. Conventional therapy with immunosuppressants and corticoids was accompanied by adverse effects and was unsuitable for further planned plastic surgeries for gender reassignment. The only effective treatment for the patient is biological therapy with dupilumab.

Immunopathological inflammation in patients with psoriasis is effectively reduced by bimekizumab treatment targeting simultaneously IL-17A and IL-17F

prof. RNDr. Jan Krejsek, CSc.

Dermatol. praxi. 2023;17(1):16-19 | DOI: 10.36290/der.2023.003  

Immunopathological inflammation in psoriasis patients is probably initiated in skin by the presence of damage associated patterns and/or patterns of microbial invasion. These patterns are identified by receptors with subsequent activation of downstream signalling pathways ultimating in transcription of several hundreds proinflammatory genes in innate immunity cells and keratinocytes. Abnormal functional polarisation of T cells into Th17 subset is mediated by regulatory axis IL-12/IL-23. T cells of Th17 subset, TcRγδ T cells, ILC3 cells and keratinocytes are rich source of IL-17A and IL-17F interleukines which playing the substantial role...

Immunotherapy in non-melanoma skin cancer

MUDr. Miroslav Důra, Ph.D.

Dermatol. praxi. 2023;17(1):20-25  

Antitumoral immunotherapy is a golden standard in modern therapy in the increasing number of metastatic or locally advanced solid tumors. This treatment achieves significant and long-lasting treatment responses and reveals prolongation of progression free survival, overall survival, together with quality-of-life improvement. In the field of malignant cutaneous tumors, the therapeutic effect of immunotherapy is well-known in metastatic melanoma, in which the immunotherapy became a standard of the modern systemic treatment. The effect of the immunotherapeutic drugs was also established in metastatic and locally advanced non-melanoma skin cancer, namely...

Plantar hyperhidrosis and foot care principles in podology practice

Mgr. Jaroslav Fešar, MBA

Dermatol. praxi. 2023;17(1):26-28 | DOI: 10.36290/der.2023.005  

Excessive sweating of the feet is one of the common health complications of both children and adults. It most often affects younger people, but it can occur at any age. Increased sweating commonly occurs after physical or mental exertion. However, if it occurs frequently and without these stimuli, it is necessary to be wary. Excessive sweating of the feet can be triggered by various diseases, medication, hormonal changes and psychological problems, but it is also often triggered by inappropriate footwear or socks and tights made of artificial, unbreathable materials. A major influence on foot sweating can be observed in people with an improper lifestyle,...

Psychodermatology in childhood

MUDr. Hana Obluková

Dermatol. praxi. 2023;17(1):29-32 | DOI: 10.36290/der.2023.006  

Psychodermatology is an interdisciplinary approach dealing with the mutual interactions between the nervous, endocrine, immune and skin systems on the one hand and behavioral outcomes on the other. Skin diseases are visible to the patient and his/her surroundings and are usually chronic with episodic character of exacerbations and remissions. They affect self-schema, arouse feelings of guilt, and are associated with myths surrounding lack of hygiene and contagiousness. Knowledge of the basics of developmental neurology and psychology is needed to assess the impact of the disease on the child's psyche. In young children, the relationship with the primary...

Treatment options for melasma and skin hyperpigmentation

MUDr. Lucia Mansfeldová

Dermatol. praxi. 2023;17(1):42-48  

Hyperpigmentation of the skin manifests itself clinically as circumscribed or diffuse darkening of the skin, which is most often caused by a disorder in the production and distribution of melanin. They are more common in people with a dark phototype due to more intense melanin synthesis. In the prevention and treatment of hyperpigmentation, it is important to treat the underlying disease that causes them. At the same time, we symptomatically remove hyperpigmentation with local lightening preparations, chemical peels, cryotherapy, microneedling, plasmatherapy, light or laser therapy. In practice, we often have to choose a combination of individual methods...

Allergic contact dermatitis versus irritant contact dermatitis

MUDr. Alena Stumpfová

Dermatol. praxi. 2023;17(1):49-54 | DOI: 10.36290/der.2023.009  

Allergic contact dermatitis and irritant contact dermatitis, collectively referred to as contact dermatitis, are some of the most common diagnoses in dermatological outpatient clinics. These are diseases caused by external substances that come into contact with the skin and, by a different mechanism, cause non-infectious inflammation of the skin. Nevertheless, their clinical picture is very similar and indistinguishable. In terms of professionalism, contact dermatitis is the most common occupational skin disease. The role of the dermatologist is associated not only with responsibility in the diagnosis and treatment of the disease, but also in the identification...

Preventing skin cancer in patients at risk

MUDr. Radana Dwayebová

Dermatol. praxi. 2023;17(1):33-37 | DOI: 10.36290/der.2023.007  

Skin cancer has an ever-increasing trend in our population, which is associated with increased exposure to ultraviolet radiation, rising numbers of individuals with a weakened immune system, as well as with continuously improving diagnostic modalities. The introduction section presents a brief overview of skin cancer and the characteristics of individuals classified as at-risk, followed by a description of ultraviolet radiation and essential prevention. The final section deals with photoprotective products with a high sun protection factor intended for skin protection in patients at risk.

Dupilumab in the treatment of atopic dermatitis

MUDr. Radek Litvik

Dermatol. praxi. 2023;17(1):38-41 | DOI: 10.36290/der.2023.008  

Atopic dermatitis (AD) is a common, inflammatory skin disease affecting adults and children with complex immunopathogenesis characterized by a dominant Th2 response. Dupilumab is the first biologic therapy available to treat AD. Its effectiveness and safety were demonstrated in many clinical trials.

Teledermatologie na 26. mítinku Evropského dermatologického fóra (EDF) - Montreux, 19.-21. 1. 2023

doc. MUDr. Karel Ettler, CSc.

Dermatol. praxi. 2023;17(1):56-58