Slovo úvodem

prof. MUDr. Ivan Rektor, CSc., FCMA, FANA, FEAN

Dermatol. praxi. 2023;17(2):63  

Care for children with epidermolysis bullosa

Mgr. Petra Šimánková

Dermatol. praxi. 2023;17(2):66-71 | DOI: 10.36290/der.2023.011  

Children with epidermolysis bullosa (EB) are a rare population with high morbidity and mortality. EB has a profound impact on the daily life of the patient and family members, on the child's physical, psychological and mental health, including disruption of social relationships. It is common for EB patients to be cared for by health professionals who are not specialized in this rare disorder. Health professionals educate parents about safety and preventive steps in caring for a child with EB, how to treat the child, how to recognize the characteristics of a wound, how to care for wounds, how to breastfeed and feed the child, etc. Increasing the knowledge...

The role of microbiome and probiotics in photoprotection and skin aging

MUDr. Tereza Chrpová Maulenová

Dermatol. praxi. 2023;17(2):72-77 | DOI: 10.36290/der.2023.012  

UV radiation significantly contributes to the acceleration of the skin aging process. After a detailed study of the microbiome of the human body, attention is now turning to the investigation of its specific representatives and their contribution to the skin ageing process and photoprotection. One of the latest trends in the fight against skin aging is probiotic skin care. Although research in this area is only in its early stages, new products are rapidly entering the market. The aim of this article is to focus attention on current knowledge about the influence of the microbiome and the possibility of using probiotics in the prevention of skin aging...

Current view on the treatment of nail psoriasis

MUDr. Gabriela Janoušková

Dermatol. praxi. 2023;17(2):78-83 | DOI: 10.36290/der.2023.013  

Psoriasis is a chronic inflammatory immune-mediated disease that affects 2-3% of the population. The prevalence of nail involvement in psoriasis patients ranges from 10 to 82%. Nail psoriasis is considered a risk factor for the development of psoriatic arthritis. It is estimated that 80 to 90% of psoriatic arthritis patients have nail involvement. Although nail manifestations have a serious negative impact on the patient's quality of life, nail psoriasis is often overlooked or ineffectively treated.

Skin care of patients undergoing radiotherapy

Mgr. Lenka Krupová, Ph.D., doc. MUDr. Ing. Jakub Cvek, Ph.D.

Dermatol. praxi. 2023;17(2):84-87  

Radiation dermatitis is a very common reaction in radiotherapy, affecting approximately 95 % of patients with varying intensity. In severe cases, it can significantly impact the quality of life. Appropriate use of clinically proven products protects the patient's skin and achieves excellent results during the treatment of skin reactions. General practitioners can significantly contribute to meeting patients' needs, reassuring them, supporting them, educating them, or supplementing information. Existing GP relationships with their patients are a good precondition for them to be able to inquire and advise without fear. Knowledge of current procedures...

Psoriasis and inflammatory bowel disease

MUDr. Kristína Gibalová

Dermatol. praxi. 2023;17(2):88-90 | DOI: 10.36290/der.2023.014  

Psoriasis is a chronic inflammatory non-infectious skin disease with a multifactorial etiology. It can occur along with other immune-mediated diseases, including non-specific intestinal inflammation. Our understanding of the underlying pathogenetic mechanisms has deepened substantially in recent decades and is developing together with new therapies targeting pathways and pro-inflammatory cytokines that have been described in association with the disease. Psoriasis and IBD not only have significant overlap, but there are also differences that affect therapy.

Ulcus cruris venosum in the context of patients' quality of life

PhDr. Iveta Ondriová, PhD., PhDr. Terézia Fertaľová, PhD., PhDr. Lívia Hadašová, PhD., MBA

Dermatol. praxi. 2023;17(2):91-93 | DOI: 10.36290/der.2023.015  

Ulcerations of the lower limbs of venous origin are caused by the initiation of a complex cascade of changes in macro- and microcirculation. Life-threatening or increased amputation of the lower limbs are very rare in venous ulcerations. The problem here is a clear deterioration of the quality of life due to chronicity, pain and demands for long-term treatment. The chronic nature of the disease results from local, general and especially physical and psychosocial problems. In the article, the authors deal with selected aspects of the quality of life in patients suffering from ulcus cruris disease.

Clinical improvement in a patient with lichen planopilaris

MUDr. Nadezhda Vidolova Brabcová

Dermatol. praxi. 2023;17(2):94-96 | DOI: 10.36290/der.2023.016  

Lichen planopilaris (LPP) is an inflammatory, primary cicatricial alopecia where hair loss is clinically evident and unfortunately remains irreversible. The goal of treatment is to stop the scarring process, reduce symptoms, and prevent further outbreaks of inflammation. Sometimes we can also choose to add treatments that stimulate the growth of hair not affected by this entity, to help alopecic areas to be less visible. In this case report I describe a patient in whom we achieved not only remission of LPP but also clinically visible improvement.

Severe form of atopic dermatitis - Successful treatment with abrocitinib

MUDr. Michaela Chmelíková, MUDr. Milena Tánczosová, Ph.D.

Dermatol. praxi. 2023;17(2):97-99 | DOI: 10.36290/der.2023.017  

Atopic dermatitis is a chronic inflammatory skin disease that affects both children and adults. It is characterized by intense itching, redness, and scaling of the skin. The pathogenesis of atopic dermatitis involves complex interactions between genetic, immunological, and environmental factors. JAK inhibitors are a new class of drugs that target the Janus kinase (JAK) signaling pathway, which plays a key role in the pathogenesis of atopic dermatitis. JAK inhibitors have been shown to effectively reduce inflammation in a variety of inflammatory diseases, including atopic dermatitis.

The skin as a mirror of the soul: successful treatment of severe atopic dermatitis in an adolescent male with dupilumab

MUDr. Michaela Nováková

Dermatol. praxi. 2023;17(2):100-103 | DOI: 10.36290/der.2023.018  

Atopická dermatitida (AD) je nejčastější chronické kožní onemocnění v pediatrické populaci. AD je spojena se zvýšeným rizikem rozvoje celé řady komorbidit, včetně asthma bronchiale, potravinových alergií, alergické rhinitidy, psychiatrických a infekčních onemocnění. AD ovlivňuje fyzické, psychické a sociální zdraví, pohodu a mezilidské vztahy, což vede k psychickému stresu. AD má tedy dopad na fyzické, sociální, školní, duševní a rodinné aspekty života dospívajících a je spojena i s některými psychiatrickými onemocněními. Zde popisujeme případ adolescentního pacienta s těžkou formou AD, úspěšně léčeného dupilumabem.

Outbreaking discovery: what if sking aged twice slower?

Mgr. Jana Kundratová, Ph.D., MBA

Dermatol. praxi. 2023;17(2):104-107  

The biological evolution of some living organisms is opening up a new path: understanding why and how we age. Organisms capable of withstanding extreme conditions are examples of perfect evolution in terms of biological robustness: their genetic adaptation by selection has helped transform a hostile environment into an optimal environment. When the extremophiles such as Deinococcus radiodurans or Arthrobacter agilis bacterias are exposed to radiation, they can transition from a "clinical death" state to a "resurrection" process through self-repair. It has been shown that ageing and age-related diseases (ARD) share the same cause:...

Zaznělo na 15. konferenci Dermatologie pro praxi Olomouc, 20. dubna 2023
První zkušenosti s inhibitorem IL-17A a IL-17F v léčbě psoriázy z FNOL

MUDr. Jan Šternberský, Ph.D.

Dermatol. praxi. 2023;17(2):108-110  

Zaznělo na 15. konferenci Dermatologie pro praxi Olomouc, 20. dubna 2023
Bimekizumab - cílená léčba psoriázy s unikátním mechanismem účinku

MUDr. Martin Tichý, Ph.D.

Dermatol. praxi. 2023;17(2):111-114  

Zaznělo na 15. konferenci Dermatologie pro praxi Olomouc, 20. dubna 2023
Akné a mikrobiom

MUDr. Renata Kučerová, Ph.D.

Dermatol. praxi. 2023;17(2):115-118