Dermatol. praxi. 2022;16(1):33-40 | DOI: 10.36290/der.2022.006

Use of zinc in dermatology in selected indications

PharmDr. Bc. Hana Kotolová, Ph.D.1, *, PharmDr. Martina Nováková1, 2, *
1 Ústav farmakologie a toxikologie, Farmaceutická fakulta, Masarykova univerzita Brno
2 Ústav aplikované farmacie, Farmaceutická fakulta, Masarykova univerzita Brno
* obě autorky přispěly stejným dílem

Zinc is an essential microelement with pluripotent biological effects. Due to the fact that our body does not have a special depot that keeps zinc in sufficient quantities, it is subject to a large metabolic turnover, and therefore an adequate daily intake of it is necessary to develop and maintain all its biological effects. Zinc has an important place in dermatology, which results from the clinical practice of dermatologists and available professional information. Positive experiences with the administration of zinc in oral and topical form occur both in the case of dermatological infections and in inflammatory dermatoses such as acne vulgaris, also in atopic dermatitis and psoriasis and in hair and mucous membrane disorders such as alopecia.

Keywords: zinc, zinc supplementation, dermatological diseases.

Published: April 4, 2022  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Kotolová H, Nováková M. Use of zinc in dermatology in selected indications. Dermatol. praxi. 2022;16(1):33-40. doi: 10.36290/der.2022.006.
Download citation

References

  1. Halboub E, Al-Maweri SA, Parveen S, et al. Zinc supplementation for prevention and management of recurrent aphthous stomatitis: a systematic review. J Trace Elem Med Biol. 2021;68:126811. doi: 10.1016/j.jtemb.2021.126811. Go to original source... Go to PubMed...
  2. Hosking AM, Juhasz M, Atanaskova Mesinkovska N. Complementary and Alternative Treatments for Alopecia: A Comprehensive Review. Skin Appendage Disord. 2019;5(2):72-89. doi: 10.1159/000492035. Go to original source... Go to PubMed...
  3. Gupta M, Mahajan VK, Mehta KS, et al. Zinc therapy in dermatology: a review. Dermatol Res Pract. 2014;2014:709152. doi: 10.1155/2014/709152. Go to original source... Go to PubMed...
  4. Park CH, Lee MJ, Kim HJ, et al. Congenital Zinc Deficiency from Mutations of the SLC39A4 Gene as the Genetic Background of Acrodermatitis Enteropathica. J Korean Med Sci. 2010;25(12):1818-1820. doi: 10.3346/jkms.2010.25.12.1818. Go to original source... Go to PubMed...
  5. Škutilová E. Zinok a jeho dôležitá a nezastupiteľná úloha v dermatológii aj v interdisciplinárnej medicíne. Súč Klin Pr. 2016;2:37-40.
  6. Wang K, Zhou B, Kuo YM, et al. A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet. 2002;71(1):66-73. doi: 10.1086/341125. Go to original source... Go to PubMed...
  7. Buchvald D. Zinok a jeho uplatnenie vo fyziológii a patofyziológii kože. Súč Klin Pr. 2014;1:55-58.
  8. Read SA, Parnell G, Booth D, et al. The antiviral role of zinc and metallothioneins in hepatitis C infection. J Viral Hepat. 2018;25(5):491-501. doi: 10.1111/jvh. Go to original source...
  9. Song D, Pan L, Zhang M, et al. Clinical use of zinc in viral warts: a systematic review of the clinical trials. J Dermatolog Treat. 2021;1-23. doi: 10.1080/09546634.2021.1942420. Go to original source... Go to PubMed...
  10. Sharquie KE, Al-Dori WS, Sharquie IK, et al. "Treatment of pityriasis versicolor with topical 15% zinc sulfate solution," Iraqi Jour. Comm. Med. 2008;21:61-3.
  11. Tan JK, Bhate K. A global perspective on the epidemiology of acne. Br J Dermatol. 2015;172 Suppl 1:3-12. doi: 10.1111/bjd.13462. Go to original source... Go to PubMed...
  12. Fox L, Csongradi C, Aucamp M, et al. Treatment modalities for acne. Molecules. 2016;21(8):1063. doi: 10.3390/molecules21081063. Go to original source... Go to PubMed...
  13. Cong TX, Hao D, Wen X, et al. From pathogenesis of acne vulgaris to anti-acne agents. Arch Dermatol Res. 2019;311(5):337-349. doi: 10.1007/s00403-019-01908-x. Go to original source... Go to PubMed...
  14. Cervantes J, Eber AE, Perper M, et al. The role of zinc in the treatment of acne: A review of the literature. Dermatol Ther. 2018;31(1). doi: 10.1111/dth.12576. Go to original source... Go to PubMed...
  15. Fivenson DP. The mechanisms of action of nicotinamide and zinc in inflammatory skin disease. Cutis. 2006;77(1 Suppl):5-10. Go to PubMed...
  16. Yee BE, Richards P, Sui JY, et al. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33(6):e14252. Go to original source... Go to PubMed...
  17. Hawkes JE, Chan TC, Krueger JG. Psoriasis pathogenesis and the development of novel targeted immune therapies. J Allergy Clin Immunol. 2017;140(3):645-653. Go to original source... Go to PubMed...
  18. Deng Y, Chang C, Lu Q. The inflammatory response in psoriasis: A comprehensive review. Clin Rev Allergy Immunol. 2016;50:377-89. Go to original source... Go to PubMed...
  19. Sheikh G, Masood Q, Majeed S, et al. Comparison of levels of serum copper, zinc, albumin, globulin and alkaline phosphatase in psoriatic patients and controls: A hospital based case-control study. Indian Dermatol Online J. 2015;6:81-83. Go to original source... Go to PubMed...
  20. Lei L, Su J, Chen J, et al. Abnormal Serum Copper and Zinc Levels in Patients with Psoriasis: A Meta-Analysis. Indian J Dermatol. 2019;64(3):224-230. Go to original source... Go to PubMed...
  21. Kilic S, Şehitoğlu HM. Correlation between psoriasis and ZIP2 and ZIP3 Zinc transporters. Turk J Dermatol. 2020;14:61-64. Go to original source...
  22. Bořilová Linhartová P, Valová S, Izakovičová Hollá L. Vrozená náchylnost k recidivující aftózní stomatitidě. Čes. Stomat. 2017;117(2):27-34. Go to original source...
  23. Ruan HH, Li GY, Duan N, et al. Frequencies of abnormal humoral and cellular immune component levels in peripheral blood of patients with recurrent aphthous ulceration. J Dent Sci. 2018;13(2):124-130. Go to original source... Go to PubMed...
  24. Ozler GS. Zinc deficiency in patients with recurrent aphthous stomatitis: a pilot study. J Laryngol Otol. 2014;128(6): 531-533. Go to original source... Go to PubMed...
  25. Al-Maweri SA, Halboub E, Al-Sharani HM, et al. Association between serum zinc levels and recurrent aphthous stomatitis: a meta-analysis with trial sequential analysis. Clin Oral Investig. 2021;25(2):407-415. Go to original source... Go to PubMed...
  26. Yildirimyan N, Özalp Ö, Şatir S, et al. Recurrent Aphthous Stomatitis as a Result of Zinc Deficiency. Oral Health Prev Dent. 2019;17(5):465-468. Go to PubMed...
  27. Urban K, Chu S, Giesey RL, et al. The global, regional, and national burden of atopic dermatitis in 195 countries and territories: An ecological study from the Global Burden of Disease Study 2017. JAAD Int. 2020;2:12-18. Go to original source... Go to PubMed...
  28. Goksor E, Loid P, Alm B, et al. The allergic march comprises the coexistence of related patterns of allergic disease not just the progressive development of one disease. Acta Paediatr. 2016;105:1472-1479. Go to original source... Go to PubMed...
  29. Maarouf M, Vaughn AR, Shi VY. Topical micronutrients in atopic dermatitis-An evidence-based review. Dermatol Ther. 2018;31:e12659. Go to original source... Go to PubMed...
  30. Makiura M, Akamatsu H, Akita H, et al. Atopic dermatitis-like symptoms in HR-1 hairless mice fed a diet low in magnesium and zinc. J Int Med Res. 2004;32:392-399. Go to original source... Go to PubMed...
  31. Takahashi H, Nakazawa M, Takahashi K, et al. Effects of zinc deficient diet on development of atopic dermatitis-like eruptions in DS-Nh mice. J Dermatol Sci. 2008;50:31-39. Go to original source... Go to PubMed...
  32. Kadiyala U, Turali-Emre ES, Bahng JH, et al. Unexpected insights into antibacterial activity of zinc oxide nanoparticles against methicillin resistant Staphylococcus aureus (MRSA). Nanoscale. 2018;10:4927-4939. Go to original source... Go to PubMed...
  33. Gray NA, Dhana A, Stein DJ, et al. Zinc and atopic dermatitis: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2019;33(6):1042-1050. Go to original source... Go to PubMed...
  34. Vojáčková N. Seboroická dermatitida, diferenciální diagnostika a léčba v praxi. Dermatol. praxi. 2016;10(1):24-27. Go to original source...
  35. Aktaş Karabay E, Aksu Çerman A. Serum zinc levels in seborrheic dermatitis: a case-control study. Turk J Med Sci. 2019;49(5):1503-1508. Go to original source... Go to PubMed...
  36. Mangion SE, Holmes AM, Roberts MS. Targeted Delivery of Zinc Pyrithione to Skin Epithelia. Int. J. Mol. Sci. 2021;22(18):9730. Go to original source... Go to PubMed...
  37. Zhang Y, Cai Y, Shi M, et al. The Prevalence of Vitiligo: A Meta-Analysis. PLoS One. 2016;11(9):e0163806. Go to original source... Go to PubMed...
  38. Yaghoobi R, Omidian M, Bagherani N. Original article title: "Comparison of therapeutic efficacy of topical corticosteroid and oral zinc sulfate-topical corticosteroid combination in the treatment of vitiligo patients: a clinical trial". BMC Dermatol. 2011;11:7. Go to original source... Go to PubMed...
  39. Huo J, Liu T, Huan Y, et al. Serum level of antioxidant vitamins and minerals in patients with vitiligo, a systematic review and meta-analysis. J Trace Elem Med Biol. 2020;62:126570. Go to original source... Go to PubMed...
  40. Dastgheib L, Mostafavi-Pour Z, Abdorazagh AA, et al. Comparison of Zn, Cu, and Fe content in hair and serum in alopecia areata patients with normal group. Dermatol Res Pract. 2014;2014:784863. Go to original source... Go to PubMed...
  41. Jin W, Zheng H, Shan B, et al. Changes of serum trace elements level in patients with alopecia areata: A meta-analysis. J Dermatol. 2017;44(5):588-591. Go to original source... Go to PubMed...
  42. MV-AISLP pro Windows, verze 1.2022.
  43. https://www.sukl.cz/leciva/rozliseni-doplnku-stravy-od-lecivych-pripravku cit.28.1.2022
  44. Růžičková Jarešová L. Dermatologická externa tuhá a polotuhá. Dermatol. praxi 2009;3(4):210-213.




Dermatology for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.