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MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2022;16(1):3  

Alopecia areata - basic disease characteristics and an overview of current and new treatment options

MUDr. Eva Štěpánková, Mgr. Pavla Boháčová, doc. MUDr. Monika Arenbergerová, Ph.D.

Dermatol. praxi. 2022;16(1):9-12 | DOI: 10.36290/der.2022.001  

Alopecia areata is an autoimmune disorder of the hair follicle typically presenting as circular, patchy hair loss on the head, but the disease can affect all body hair and lead to complete hair loss. Diagnosis is based on clinical features and is made by trichoscopy and histopathological examination. The most common treatment is local or intralesional application of corticosteroids. Topical immunomodulators such as diphencyprone or dithranol are suitable for more progressive forms. Systemic immunosupresive drugs have some adverse effects and after finishing treatment there is a risk of relapse. Of the new therapeutic options in the near future, the...

Current view on urticaria - causes of urticaria occurrence, diagnosis and current treatment options

MUDr. Barbora Jankovičová

Dermatol. praxi. 2022;16(1):13-16 | DOI: 10.36290/der.2022.002  

Urticaria is a common disease that more than 20% of the general population has experienced during their lifetime. It is caused by mast cells and manifests with characteristic urticarial pimples, angioedema or both symptoms simultaneously. In recent years, it has gained more attention from clinicians and researchers, most likely due to the approval of the anti-IgE antibody biologic treatment omalizumab. This review article focuses on the current view of urticaria, its causes, diagnosis and current treatment options.

Dermatoses in pregnancy

MUDr. Filip Rob, Ph.D.

Dermatol. praxi. 2022;16(1):17-21 | DOI: 10.36290/der.2022.003  

During pregnancy physiological and pathological changes occur due to hormonal and immunological changes. Most of these changes are benign in nature and do not endanger the mother or the fetus, however, they can have a significant impact on a woman's quality of life during pregnancy. Moreover due to the potential teratogenic or toxic effect of some drugs, therapeutic options may be limited in some cases. Pregnancy dermatoses form a separate group of diseases, which include gestational pemphigoid, intrahepatic cholestasis in pregnancy, atopic eruptions in pregnancy, and polymorphic eruptions in pregnancy. Recognizing them can sometimes be difficult,...

Microbiome and probiotics in the context of dermatology

MUDr. Tereza Chrpová Maulenová

Dermatol. praxi. 2022;16(1):22-27 | DOI: 10.36290/der.2022.004  

Current knowledge suggests that the microbiome affects its host much more than it was previously thought. It does so directly, through biologically active substances produced by the microorganisms and indirectly, by modulating the host's immune system. Thus, the microbiome plays a key role in maintaining homeostasis. Under certain circumstances, an imbalance in this ecosystem can lead to the manifestation of a number of diseases, including some skin diseases, such as atopic dermatitis, psoriasis, acne and others. Probiotics then open a new path in the treatment of these conditions.

Skin manifestations COVID-19

MUDr. Slavomír Urbanček, MUDr. Petra Fedorcová

Dermatol. praxi. 2022;16(1):28-31 | DOI: 10.36290/der.2022.005  

Viral rashes are well-known group in dermatology. Coronavirus-2 (SARS-CoV-2) pandemy affecting millions of people revealed large spectrum pulmonal and extrapulmonal symptoms. Dermatologic manifestations could be divided into 6 groups: urticarial rash, confluent erythematous/maculopapular/morbilliform rash, papulovesicular exanthem, chilblain-like acral pattern, livedo reticularis/racemosa-like pattern and purpuric "vasculitic" pattern. Paper summarizes current knowledges with respect to incidence, clinical picture a relationship of rashes to the course and severity of COVID-19 infection.

Use of zinc in dermatology in selected indications

PharmDr. Bc. Hana Kotolová, Ph.D., PharmDr. Martina Nováková

Dermatol. praxi. 2022;16(1):33-40 | DOI: 10.36290/der.2022.006  

Zinc is an essential microelement with pluripotent biological effects. Due to the fact that our body does not have a special depot that keeps zinc in sufficient quantities, it is subject to a large metabolic turnover, and therefore an adequate daily intake of it is necessary to develop and maintain all its biological effects. Zinc has an important place in dermatology, which results from the clinical practice of dermatologists and available professional information. Positive experiences with the administration of zinc in oral and topical form occur both in the case of dermatological infections and in inflammatory dermatoses such as acne vulgaris, also...

A case report of an oligophrenic patient with peripheral T-cell lymphoma

MUDr. Petra Chovancová

Dermatol. praxi. 2022;16(1):41-44 | DOI: 10.36290/der.2022.007  

The case report describes the case of a 45-year-old oligophrenic patient who was brought to Kyjov Hospital with suspected highly infectious skin disease. Numerous nodules and skin ulcers dominated to the clinical picture. After an examination by a dermatovenerologist was suspected lymphoproliferative disease. It was subsequently confirmed by the histological examination. The whole hospitalization of the patient was accompanied by a strong fear of nursing staff and non-cooperation in moderate-grade mental retardation.

Gorlin-Goltz syndrome - case report

MUDr. Martina Blažková

Dermatol. praxi. 2022;16(1):45-47 | DOI: 10.36290/der.2022.008  

Gorlin-Goltz syndrome or basal cell nevus syndrome is a rare genetically inherited disease. Most imortant skin manifestation are multiple basal cell carcinomas in a young age or even in a childhood. Gorlin-Goltz syndrome is connected with multiple comorbidities. In our case report we describe 27-years old men with a presence of multiple basal cell carcinomas, history of odontogenic keratocysts, facial abnormalities and calcification of meninges. Multidisciplinary dispensarisation has been provided since a confirmation of diagnosis.

Therapeutic Use of Food Supplements as a Prevention against its Ageing

doc. MUDr. Jiří Slíva, Ph.D.

Dermatol. praxi. 2022;16(1):52-54 | DOI: 10.36290/der.2022.010  

As the skin ages, the epidermis thins, although the number of cell layers remains unchanged. Ageing skin is thinner, paler and brighter (translucent). Even with regard to the demographically ageing population, the demand for effective tools offering a reversal or at least a slowdown in involution processes is rising. The presented text briefly discusses the most frequently used options of oral supplementation with food supplements, which promise such effects.

15. konference Akné a obličejové dermatózy

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2022;16(1):55-58 | DOI: 10.36290/der.2022.011  

Diagnostic Algorithms in Dermoscopy and Their Use - A Review

MUDr. Miroslav Důra, Ph.D.

Dermatol. praxi. 2022;16(1):48-51 | DOI: 10.36290/der.2022.009  

The article presents a review of the commonly used diagnostic algorithms in dermoscopy and their potential use in daily practice. Their usefulness, diagnostic accuracy and limitation are discussed. Several examples of the algorithm application in melanocytic lesions are added. Focusing on one single cutaneous lesion without correlation to other patient's lesions is the main limitation of the dermoscopic diagnostic algorithms. The diagnostic algorithms usually do not incorporate growth dynamics, personal and family medical history. Dermoscopic diagnostic algorithms could be a useful tool for a dermatologist mainly in his residency. Nevertheless, experience...