Dermatol. praxi. 2022;16(4):205-210 | DOI: 10.36290/der.2022.041
Adverse effects of systemically administered drugs on the skin
- Klinika nemocí kožních a pohlavních LF UK a FN Hradec Králové
Adverse effects of systemic therapy can also be observed on the skin. Pharmacological (predictable) and idiosyncratic (unpredictable) responses are distinguished. Drug allergy is also included here, most often type IV (e. g., toxic epidermal necrolysis). The temporal relationship between an adverse reaction and drug intake is important for establishing the diagnosis; laboratory tests and in-vivo exposure tests are used for confirmation. Treatment measures primarily include discontinuing the suspected medication. In addition, topical dermatological treatment and, in more severe cases, systemic therapy can be provided (antihistamines, corticoids, and/or immunosuppressants, IVIG, biologicals). An entry in the patient's medical record is important.
Keywords: cutaneous adverse drug reactions, SJS, TEN, diagnostic tests - management.
Accepted: November 29, 2022; Published: December 1, 2022 Show citation
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