Slovo úvodem

PhDr. Václav Mertin

Dermatol. praxi. 2013;7(4):149  

Conventional treatment of chronic plaque psoriasis in the era of biological drugs

MUDr.Alena Machovcová, Ph.D., MBA

Dermatol. praxi. 2013;7(4):152-155  

Despite undeniable progress in the treatment, psoriasis still remains an incurable condition. Systemic treatment is indicated in patients with moderate and severe forms of plaque psoriasis or with other forms of psoriasis. Conventional systemic treatment utilizes retinoids, ciclosporin or methotrexate with a varied effect and, more recently, modern biological therapy has been used which is very effective. The article deals with systemic psoriasis treatment prior to initiation of biological therapy, evaluation of treatment efficacy, and side effects of treatment.

Atopic eczema and pimecrolimus

MUDr.Lucie Růžičková Jarešová

Dermatol. praxi. 2013;7(4):156-157  

Atopic eczema is a pruritic chronic skin condition. The initial manifestations can occur at any age; however, in general, they occur in two thirds of patients by two years of age. The aetiopathogenesis of atopic eczema is multifactorial with local cutaneous, neurohumoral, and immunological abnormalities. The consumption of corticosteroids still remains high. Immunomodulators are drugs that reduce the consumption of hormonal products. Elidel is among the first-choice drugs when the condition occurs on sensitive sites of the skin. According to the 5-year Petite study 2004–2010, in which infants aged 3 to 12 months were included at study...

Systemic treatment of psoriasis

MUDr.Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2013;7(4):160-164  

Psoriasis is a chronic, inflammatory hyperproliferative disease of the skin, scalp, nails and joints. It belongs to a group of papulosquamosus skin disorders and is presented by a variety of clinical presentations. Basic treatment is a local therapy. Another treatment option is a phototherapy, first of all PUVA and 311 nm methods. Systemic treatment is reserved for severe cases refractery to standard local therapy and phototherapy and for inicially very severy cases. There are three therapeutics for first line of systemic treatment: acitretin, cyclosporin A and methotrexat. The second line systemic medicaments are biologics; adalimumab, etanercept,...

Superficial candidiases and treatment options

doc.MUDr.Růžena Pánková, CSc.

Dermatol. praxi. 2013;7(4):166-169  

Candidiasis is the most frequent mycosis with a number of different clinical presentations of varying severity. Superficial candidiases include intertriginous candidiasis; mucosal candidiasis – oral, vulvar and vaginal; balanitis and balanoposthitis; paronychial candidiasis; and chronic mucosal and cutaneous candidiasis. The clinical course is usually chronic and recurrent; however, there may be candidiases with a severe, life-threatening course. The diagnosis should be established based on evaluation of history, clinical finding, native microscopy, and culture result. Most Candida infections (more than 90%) are caused by five most commonly...

The role of ceramide in the skin barrier function, their importance in the development of skin diseases

prof.emer.MUDr.Jiří Záhejský, DrSc.

Dermatol. praxi. 2013;7(4):170-174  

and their treatment The epidermal barrier plays an important biological function in the limitation and regulation of penetration of the externally effective substances and factors of environmental life milieu (f. e. UV rays) and factors which influence the hydratation of skin surface. It requires a continuous renewal of epidermal barrier structures. The continuous renewal (s.c. biological restoration) from the basal layer requires an accelerate mitotic activity of basal cells with an accelerate reproduction of a new population of keratinocytes and an increased enzymes activity for ceramide synthesis. The lamellar lipid-systems of a ceramide...

Bacterial and yeast lysates and the use in the clinical practice

doc.MUDr.Jaromír Bystroň, CSc.

Dermatol. praxi. 2013;7(4):175-179  

The author presents an overview of the mechanisms of action of bacterial immunomodulators and discusses the indications and the most common issues concerning the use of bacterial lysates in clinical practice.

Severe case of ulcerative skin lesions

MUDr.Jana Čechovičová, MUDr.Lubomír Drlík

Dermatol. praxi. 2013;7(4):180-182  

Calciphylaxis is characterized by ischemic ulcerative skin lesions and high mortality. It develops as a complication of renal insufficiency in many cases. Pyoderma gangrenosum belongs to neutrophilic dermatosis and it’s associated with systemic diseases. Authors report two cases of these serious ulcerative skin lesions, their clinical and histological features, diagnostic and therapy possibilities.

Vyšetřování kožních mykóz, onychomykóza a terapie

MUDr.Lucie Růžičková Jarešová

Dermatol. praxi. 2013;7(4):183-184