Začněme výživou …

Ing. Ivan Mach, CSc.

Dermatol. praxi. 2014;8(1):3  

Defects of innate immunity - new pathogenetic aspects of atopic dermatitis

doc.MUDr.Dušan Buchvald, CSc.

Dermatol. praxi. 2014;8(1):6-10  

A growing body of evidence suggests that there are a variety of defects in the innate immune system that collectively affect the development and severity of atopic dermatitis. Genetically based impairment of the epidermal barrier, modifications of pattern recognition receptors and deficiency of antimicrobial peptides facilitate the entry of allergens and infectious microbes into the skin, where they encounter immunocompetent cells. The defects of innate immunity not only encourage the evolution of immediate type hypersensitivity to atopic allergens, but also explain susceptibility of atopic dermatitis patients to pathogens such as Staphylococcus...

Acne tetrada and biological treatment options

MUDr.Eliška Langerová

Dermatol. praxi. 2014;8(1):11-14  

Acne tetrada is a syndrom consisting of acne conglobata, hidradenitis suppurativa, perifolliculitis capitis abscedens et suffodiens and sinus pilonidalis. The conventional systemic therapy includes antibiotics, retinoids, imunosupressive therapy, peroral antidiabetics, sulphons, surgical methods and in women hormonal therapy. “Biological era“ reveals new methods of treatment. Besides psoriasis gets the harsh forms of acne to the point of interest of biological treatment nowadays. Acne is imunologically mediated desase with incerased levels of tumor necrosis factor alfa (TNF-α). Positive effect of therapy using anti TNF-α...

Follicular bounded skin inflammation

MUDr.Veronika Paťavová, MUDr.Lubomír Drlík

Dermatol. praxi. 2014;8(1):15-16  

Folliculitis is an inflammatory process involving any part of the hair follicle. It is important to recognize noninfectious causes of folliculitis (e. g. eosinophilic folliculitis) as well as folliculitis primarily involving the scalp (e. g., folliculitis decalvans). The condition manifests clinically as erythematous papules or pustules around hair follicles, histologic examination reveals various populations of inflammatory cells around the pilosebaceous unit.

Genital herpes in women

doc.MUDr.Jozef Záhumenský, Ph.D.

Dermatol. praxi. 2014;8(1):17-19  

Authors summarize recent opinions on epidemiology, symptoms and treatment of genital herpes. Recently incidence of the primary manifestations of infection in the genital area in young women is increasing. The causative agent is paradoxically more likely to herpes simplex virus type I, which is classically find in labial herpes. Dangerous is the occurrence of genital herpes during pregnancy, when is possibility of vertical transmission and infection of the newborn with a severe course. Caesarean section and antiviral prophylaxis can reduce this risk to a minimum. In conclusion, the authors attach a short case report of repeated incorrect diagnosis...

Perifolliculitis abscedens et suffodiens in patient succesfully treated with izotretinoid

MUDr.Helena Korandová, CSc.

Dermatol. praxi. 2014;8(1):20-22  

Perifolliculitis abscedens et suffodiens is a rare chronic dermatosis of unknown origin that affects hairy scalp and neck. It is a part of acne tetras and is present mostly in men over 20 years of age. Histopathology is necessary to asses the diagnosis. Peroral izotretinoin is the first choice of the treatment. Other therapeutic modalities include surgery, antibiotics, dapsone and biological therapy (anti- TNFα). A case of man treated succesfully with izotretinoin is described.

Allergic reactions to gold

doc.MUDr.Dagmar Ditrichová, CSc., MUDr.Iva Karlová

Dermatol. praxi. 2014;8(1):23-25  

The increasing frequency of sensitization to gold especially in developed countries was noticed recently. The sources of sensitization are except for jewelry, dental materials and oral gold treatment also intracoronary Au stents and other implants. The papular dermatitis is the most common clinical picture especially on the face, eyelids, near the ears and on the hands. Typical lichenoid lesions on the oral mucous membranes or nonspecific stomatitis are frequently seen. Gold sodium thiosulfate 2% in petrolatum is recommended for patch tests with subsequent reading of skin reactions on day 2 and day 3 of exposure, with follow-up on day 7.

Cutaneous metastases of gastric carcinoma

MUDr.Veronika Dedková, doc.MUDr.Lumír Pock, CSc.

Dermatol. praxi. 2014;8(1):26-28  

Cutaneous metastases of internal malignancies are relatively uncommon. Their average incidence is 0,7–10,4% (1). Metastasis generally occurs after an internal malignancy had been discovered and signifies disseminated disease with a poor prognosis. Skin metastases from gastric adenocarcinoma are rare, it has been reported in only 6% in males and 1% in females of all skin metastases (2). We report a case of 83 years old woman with relatively massive erruption of cutaneous metastasis from gastric adenocarcinoma, which was the first sign of this desease.

Next types of wound dressing - news, use, aplication

RNDr.Romana Mrázová, Ph.D.

Dermatol. praxi. 2014;8(1):29-32  

Appropriately selected therapeutic materials for moist wound healing and to educate patients and their families not only helps healthcare professionals in the care of patients with leg ulcers, pressure ulcers, diabetic foot ulcers, but also ensures the quality of life of the patient. We must not forget the economic profitability, which can be achieved using appropriate therapeutic material which corresponds to the phase of healing. If we look into the current General Health Insurence Company, we find that a group of 01, and where were these new groups of medical devices regularly added, is for ordinary users and non-serving little transparent...

Celková terapie v dermatologii I

MUDr.Lucie Růžičková Jarešová

Dermatol. praxi. 2014;8(1):33-35  

XVII. olomoucká dermatologická konference

Dermatol. praxi. 2014;8(1):36-38