Hovory o zdraví aneb Naslouchejme pacientům

PhDr. Lucie Klůzová Kráčmarová

Dermatol. praxi. 2017;11(1)  

Rosacea

doc. MUDr. Růžena Pánková, CSc.

Dermatol. praxi. 2017;11(1):6-11 | DOI: 10.36290/der.2017.002  

Rosacea is a common, chronic, relapsing inflammatory skin condition consisting of various subtypes and degrees of severity. In 2002, rosacea was classified and standardized by the National Rosacea Society Expert Committee into 4 recognized subtypes, although these patterns often overlap in clinical practice. There are rarer pediatric and granulomatous presentations. Uncommon skin condition is persistent edema of rosacea. Several theories regarding the etiology of rosacea exist: a genetic component, but a rosacea gene has not been detected yet; an altered innate immune response; the presence of characteristic facial or ocular inflammation involving...

Actinic keratosis and the importance of photoprotection

MUDr. Patrícia Bakšiová

Dermatol. praxi. 2017;11(1):12-15 | DOI: 10.36290/der.2017.003  

Actinic keratosis is very common epithelial tumor, from which to be developed squamous cell carcinoma, therefore deemed sometimes for squamous cell carcinoma in situ. The vast majority of actinic keratoses occurs in people with fair skin. The diagnosis usually the certificate may be used dermatoscopy. Treatmens are surgical and non- surgical methods. Photoprotecion is an inportant preventiv in the development of skin tumors

Cutaneous infections caused by papillomaviruses

MUDr. Iva Obstová

Dermatol. praxi. 2017;11(1):16-20 | DOI: 10.36290/der.2017.004  

This article reviews cutaneous infections caused by papillomaviruses, and discusses current possibilities of topical and systemic therapy, including their indications and contraindications.

News in the treatment with peroral isotretinoin

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2017;11(1):22-26 | DOI: 10.36290/der.2017.005  

Acne is a polymorphic inflammatory disease of a pilosebaceous unit. Peroral isotretinoin belongs to the first non-aromatic generation of retinoids and is the most effective medicine in acne treatment. It is indicated first of all for a therapy of severe and resistent forms of acne. The therapy should by directed only by a dermatologist who is experienced in the treatment with this medicine. In the article the latest recommentations for isotretinoin therapy including special arrangement for women are described.

Treatment of patient with severe chronic plaque psoriasis, our experience with secukinumab

MUDr. Jitka Ošmerová, MUDr. Olga Faustmannová, Ph.D., MBA, prof. MUDr. Alena Pospíšilová, CSc.

Dermatol. praxi. 2017;11(1):28-30 | DOI: 10.36290/der.2017.006  

Psoriasis is a chronic inflammatory skin disease affecting 2–4 % of the population in Central Europe with significant impact on the physical, mental and social aspects of the individuals life. This disease affects not only the skin, but is associated with a number of comorbidities, the most common being psoriatic arthritis. This case report describes a patient with a very severe course of the disease, characterized by recurrent secondary lack of efficacy of treatment.

Pembrolizumab in II. line therapy of metastatic BRAF-mutated malignant melanoma Case report of long-term remission after vemurafenib treatment failure

MUDr. David Šulc, MUDr. Jana Pukyová, MUDr. Martina Chodacká, MUDr. Aleš Chodacki

Dermatol. praxi. 2017;11(1):32-34 | DOI: 10.36290/der.2017.007  

Actually we have two challenging treatment options for treatment of metastatic BRAF-mutated malignant melanoma. These are BRAF inhibitors and anti-PD-1 antibodies. Here we present a clinical case of treatment sequence vemurafenib/pembrolizumab.

Acute urticaria and treatment of dental focus

MUDr. Eva Pospíšilová

Dermatol. praxi. 2017;11(1):35-38 | DOI: 10.36290/der.2017.008  

Acute urticaria is a frequent disease various etiology characterized by sudden appearance of wheals – urticaria, swelling of the affected area and other general symptoms. The article describes the case of a 34 years old woman with the emergence of acute urticaria after taking analgesics for the treatment of acute pulpitis and tooth caries.

10. konference Akné a obličejové dermatózy

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2017;11(1):43-46  

Hydroquinone and tretinoin – new substances for extemporaneous preparation

Mgr. Lukáš Láznička, PharmDr. Veronika Bucharová

Dermatol. praxi. 2017;11(1):39-42 | DOI: 10.36290/der.2017.009  

Hydroquinone and tretinoin are newly available substances for extemporaneous preparation. Thanks to them is possible to prepare creams for treating skin hyperpigmenation. Formulas containing tretinoin can replace unavailable medicinal products, choose a different concentration of the drug or to prepare other dosage forms, which are not available in registered medicinal products.