Dermatology for Practice, 2017, issue 2

Editorial

Hovory o zdraví aneb naslouchejme pacientům

PhDr. Lucie Klůzová Kráčmarová

Dermatol. praxi. 2017;11(2)

Review articles

Advances in biological therapy for psoriasis

MUDr. Alena Machovcová, Ph.D., MBA

Dermatol. praxi. 2017;11(2):55-57 | DOI: 10.36290/der.2017.012

In spite of indisputable progress achieved in treating this condition, psoriasis still remains an incurable disease. Biological therapy has brought a revolution in the treatment of psoriasis. Clinical trials are still being carried out and new treatment options for severe psoriasis and psoriatic arthritis are emerging. Recently, anti-interleukin 17 antibodies have begun to be used in treating psoriasis and psoriatic arthritis.

Fabry disease – an overview for a dermatologist

MUDr. Lukáš Lacina, Ph.D., MUDr. Ondřej Kodet, Ph.D.

Dermatol. praxi. 2017;11(2):58-62 | DOI: 10.36290/der.2017.013

Fabry disease (also referred as Fabry-Andrerson disease, alpha-galactosidase A deficiency, ceramide-trihexosidase deficiency, OMIM 301500) is a rare genetic disease, which was described more than one century ago (1898) based on typical clinical manifestation. The very first name „angiokeratoma corporis diffusum“ was coined due to the most visible cutaneous manifestation. However, this is not the only and exclusive dermatological feature in this condition. Early and correct recognition of symptoms of multi-systemic disease might have and direct impact on life of patient. Similarly to several other monogenic diseases, the defective gene...

Diseases and pathology of the nails

MUDr. Alena Stumpfová

Dermatol. praxi. 2017;11(2):64-70 | DOI: 10.36290/der.2017.014

The nail is a keratinised derivative of the skin covering the distal portion of the finger tip. There is not only one way how to look into the issue of the pathology of the nail unit as it is a broad topic. Diseases can be divided into the several parts according to the clinical appearance, descriptive characteristics, localisation or the causes of the damage. Particular part of it is summarised in this article, in which mainly the ethiology is discused.

Interdisciplinary overviews

Summertime and children’s skin from the perspective of a general practitioner

MUDr. Veronika Tolašová, MUDr. Miroslav Kobsa, MBA

Dermatol. praxi. 2017;11(2):71-78

The article deals with summertime in relation to children, describing the effect of sunlight on the children’s skin, presenting some summertime dermatitides encountered by the general practitioner as well as some pathological conditions associated with sun exposure (photodermatitis), and briefly discussing the issue of paediatric malignant melanoma. Also included is practical advice on skin photoprotection and an overview of some protective agents suitable for children.

Case report

Chronic spontaneous urticaria treated with bilastin

MUDr. Dana Prusíková

Dermatol. praxi. 2017;11(2):79-82 | DOI: 10.36290/der.2017.016

Chronic spontaneous urticaria is characterized by spontaneously arising itchy wheals and/or angioedema presents on regular basis for longer than 6 weeks. The average duration of the disease is 1–5 years but is likely to be longer in more severe cases. In the majority of cases, the cause remains unknown. Infections, especially those affecting the upper respiratory and gastrointestinal tracts, have been associated with some cases of CSU, however, recent data indicate this association is more likely coincidental than causal. The intolerance to pseudoallergens in foods may contribute to disease activity. Mainstay of treatment for the vast majority...

Paracetamol induced Stevens-Johnson syndrome and toxic epidermal necrolysis overlap syndrome

MUDr. Tereza Chrpová Maulenová

Dermatol. praxi. 2017;11(2):83-85 | DOI: 10.36290/der.2017.039

Stevens–Johnson syndrome and toxic epidermal necrolysis are severe and potentially life-threatening skin conditions caused most frequently by a hypersensitive reaction to medication. Paracetamol, which is the most frequently used pharmaceutical mean for fever and aches, appeared to be a relatively safe medication in a clinical practice. However, there have been several cases of severe post-medical reactions described in the literature. In this article, we present a case report of a patient with Stevens–Johnson syndrome and toxic epidermal necrolysis overlap syndrome following paracetamol use.

Resistant form of severe plaque psoriasis successfully managed with secukinumab

MUDr. Martin Tichý, Ph.D.

Dermatol. praxi. 2017;11(2):86-88 | DOI: 10.36290/der.2017.017

Secukinumab, IL 17A inhibitor, belongs to the newer group of biological agents which are registered for therapy of severe plaque psoriasis. The results of clinical trials and present clinical experience show very good efficacy and safety of secukinumab. Good experience in the therapy of resistant and complicated forms of psoriasis is documented on concrete clinical case.

Cosmetic dermatology spot

Chemical peeling to remove pigmentations

MUDr. Kateřina Fajkošová

Dermatol. praxi. 2017;11(2):92-95

Chemical peeling is most often used as an adjunct to acne treatment as well as for rejuvenation and pigmentation lightening. However, not all skin pigments are suitable for lightening with chemical peeling. First, it is necessary to precisely diagnose the pigmented spot intended to be lightened or removed, and next to determine the appropriate method of treatment. Another possible and more modern method of removing some pigmentations is laser treatment. Although this treatment is usually more effective, it is a method that is not always readily available; therefore, chemical peeling still has its place in the practice. Some newly produced chemical...

OTC drugs

Preparations intended for the care of the skin suffering from atopic dermatitis

Mgr. Jana Martinásková

Dermatol. praxi. 2017;11(2):96-101 | DOI: 10.36290/der.2017.019

The article discusses the current knowledge regarding the predisposition to develop atopic dermatitis. Summarizes generally known recommendations for skin care suffering from AD. The surveillance tables provide examples and composition of OTC dermocosmetics and medicines that are available in pharmacies. The examples given dermocosmetics brands were selected based on their market position, long-term experience of the companies in the development of the products, collaboration with dermatologists and based on the positive response to the patient’s side.