Medicína musí udělat několik nepopulárních kroků, aby zůstala čistá a užitečná
1. Pojetí ČLOVĚKA ve zdraví a nemoci

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2019;13(2)  

Pregnancy, maternity and plaque psoriasis

MUDr. Filip Rob, Ph.D.

Dermatol. praxi. 2019;13(2):63-67 | DOI: 10.36290/der.2019.022  

Pregnancy is an immunologically very specific period in which numerous immunomodulatory changes occur allowing growth of the fetus in the mother‘s body. These changes affect the course of psoriasis and may make psoriasis worse. Moreover psoriasis itself as a systemic inflammation affects the course of pregnancy, especially in women with serious disease the effect may be negative. Because the most commonly used systemic drugs are contraindicated in pregnancy and clinical trials cannot be performed on pregnant women, lack of experience with efficacy and safety of mainly new biological drugs complicates treatment decisions. Thus, treatment of pregnant...

Current approach to photoprotection

MUDr. Viktor Palla

Dermatol. praxi. 2019;13(2):68-70 | DOI: 10.36290/der.2019.010  

Solar radiation reaching the earth’s surface has an undeniable impact on the human body. In both the short and long term, it canlead to serious skin changes that are particularly caused by the UVA and UVB parts of the ultraviolet spectrum. Therefore, consistentand comprehensive protection is required. This currently involves wide-spectrum sunscreens, certified protective clothing,and good-quality sunglasses. In addition, it is necessary to behave responsibly and take into account the current conditions ofthe surrounding environment. It is also imperative to use all these means from childhood.

Vitiligo: diagnosis and therapy

MUDr. Karolína Bortelová

Dermatol. praxi. 2019;13(2):72-75 | DOI: 10.36290/der.2019.011  

Vitiligo is a skin disorder resulting in the appearance of white, sharply delimited macules on the skin. It is usually diagnosed clinically, although in case of ambiguity, Wood lamp or skin biopsy can be used. There are currently many options for vitiligo therapy, local preparations, phototherapy and surgical treatment are available. Local corticosteroids or topical immunomodulators for localized vitiligo and phototherapy for generalized vitiligo are considered as the first choice. Since treatment often takes a long time, and not always a cosmetically acceptable result, we encounter patients with frustration and increased mental stress, so it is good...

Current trends in the treatment of skin allergies

MUDr. Gabriela Janoušková, MUDr. Alena Machovcová, MBA

Dermatol. praxi. 2019;13(2):76-79 | DOI: 10.36290/der.2019.012  

Allergic disease have got a long history. They can manifest themselves in various organs, usch as skin, gastrointestinal and respiratorytract, and comprise disease as allergic rhinitis, conjuctivitis, bronchial asthma, oral allergy syndrome, food allergy, urticaria,atopic eczema and contact dermatitis.The actual treatment options for urticaria and atopic dermatitis are discussed in this article.

Severe form of atopic dermatitis – candidate for dupilumab therapy

doc. MUDr. Spyridon Gkalpakiotis, Ph.D, MBA, MUDr. Milena Tánczosová

Dermatol. praxi. 2019;13(2):80-82 | DOI: 10.36290/der.2019.013  

Atopic dermatitis is a chronic inflammatory skin disease affecting between 1 and 3 % of adult population. The incidence in children iseven higher. Due to significant itching, other subjective problems, and also the visibility of the lesions significantly reduces the qualityof life. In localized forms, topical therapies are often sufficient, but systemic therapy is needed in generalized settings. Here we describethe case of a patient with severe atopic dermatitis who has failed classical systemic therapy and is a suitable candidate for biologictreatment with dupilumab.

Amyloidosis – a case of patient with nodular amyloidosis at inzulin injection sites

MUDr. Andrea Marešová

Dermatol. praxi. 2019;13(2):83-85 | DOI: 10.36290/der.2019.014  

Cutaneous amyloidosis is a group of clinically different forms. It occurs either separetely without involving other tissues or it may be apart od systemic amyloidosis. Specific subtype of nodular form of amyloidosis is AIns ( Amyloidosis at inzulin injection sites), where theinzulin itself is an amyloidogenic protein. This form is likely underdiagnosed in view of the fact that clinically similars to lipohypertrophy.

Pacient s psoriázou a metabolickým syndromem
Oddálení nutnosti systémové léčby psoriázy díky aplikaci pěny Enstilar®

MUDr. Simona Vachatová

Dermatol. praxi. 2019;13(2):108-110  

Practical aspects of photoprotection

PharmDr. MVDr. Vilma Vranová, Ph.D., Václava Valešová

Dermatol. praxi. 2019;13(2):96-102  

UV radiation-induced skin damage can occur in people of all phototypes. The level of exposure to UV radiation in childhood is oneof the factors that increase the risk of developing skin cancer later in adulthood. Photoprotection involves behaviour modificationwhile staying in the sun and combined protection with clothing, sunglasses, head cover, and appropriate sunscreen.

Summary of current over‑the‑counter

PharmDr. Veronika Bucharová

Dermatol. praxi. 2019;13(2):86-90 | DOI: 10.36290/der.2019.023  

Self-treatment of numerous skin diseases is very commonly seen at the pharmacy. Wide range of the over-the-counter medicinalproducts regarding patient’s specific requestes and actual stage of his illness can be recommended. There are the over-thecountermedicinal products available for the treatment of the cold sores, pressure blisters, vulgar warts and corns, which are themost common dermatological problems treated by the patient, introduced in this article. Primary over-the-counter medicinalproducts used in the treatment of herpes and warts are summarized in the tables.

Morbus Fabry – skin and soft‑tissue manifestations

MUDr. Gabriela Dostálová, Ph.D.

Dermatol. praxi. 2019;13(2):103-106 | DOI: 10.36290/der.2019.016  

Fabry disease (FD, OMIM 301500) or Fabry-Anderson disease, is a rare, X chromosome-linked progressive lysosomal storage disease. Mutations in the GLA gene are resposible for deficiency of alpha-galactosidase A (alpha-gal A), which is the cause of the accumulation of neutral glycosphingolipids, mainly globotriaosylceramide (Gb3), within various tissue types. The disease brings on variety of neurologic, renal, cardiovascular, ophthalmologic or dermatologic symptoms. The disease can manifests at any age from early childhood to late aduthood. A precise cooperation of a multidisciplinary team is necessary for an early diagnosis of Fabry disease, with dermatologist...

Kongres AAD (Americká akademie dermatovenerologie) ve Washingtonu (USA), 1.– 5. 3. 2019

doc. MUDr. Karel Ettler, CSc.

Dermatol. praxi. 2019;13(2):107  

Hard life of a patient with psoriasis – treatment from psychodermatological point of view

MUDr. Miroslav Kobsa MBA, MUDr. Marie Selerová, Ph.D.

Dermatol. praxi. 2019;13(2):92-95 | DOI: 10.36290/der.2019.015  

Psoriasis is a common chronic multifactorial disease which has a serious impact on patients lives and can result in restrictions tosocial activities. It is a psychosomatis disease, the skin and psyche are closely linked. Patients tend to anxiety, depression. It isneccecery to identifying patients who need support with psychosocial and psychological problems.