Celiakie, co o ní víme v roce 2020?

prof. MUDr. Jiří Nevoral, CSc.

Dermatol. praxi. 2020;14(2):59  

Treatment of psoriasis

MUDr. Jorga Fialová, MUDr. Martina Kojanová, Ph.D.

Dermatol. praxi. 2020;14(2):63-70 | DOI: 10.36290/der.2020.011  

Psoriasis is a chronic inflammatory immune-mediated systemic disease. The therapeutic options depend on many factors. In recent years, systemic treatment of psoriasis has made significant progress. In order to optimize and individualize the treatment, the guidelines have been developed. Despite their regular updates, new scientific knowledge and up-to-date guidance should be followed.

Chronic venous disease underestimated by both patients and physicians: surprising results of a Czech survey

MUDr. Júlia Černohorská, Ph.D.

Dermatol. praxi. 2020;14(2):71-76  

Chronic venous disease (CVD) is underestimated by both patients and physicians. Various surveys suggest that patients underestimate their symptoms and often seek medical attention late in the course of the disease, i.e. either with advanced varices or with permanent skin changes resulting from severe haemodynamic disturbances in the venous system. Moreover, there are increasing numbers of patients with a non-healing wound of venous aetiology. In fact, more advanced stages of CVD significantly reduce the quality of life of patients. The 2019 CVD control survey carried out in the Czech Republic indicates that, particularly among younger patients, there...

Thermal injury of skin

doc. MUDr. Karel Ettler, CSc., MUDr. Jiří Ettler

Dermatol. praxi. 2020;14(2):77-80  

High temperatures applied directly on the skin surface for a sufficient amount of time cause thermal burns. Similar damage in skin can be induced by ionising and solar irradiation. Protective measures could prevent both of them. Contact with high temperature for a long period of time provokes livedo (erythema ab igne). Low or freezing temperatures cause frostbites. Exposition to lower temperatures for a long period of time induces perniones.

Practical approach to hemangiomas in outpatient practice

MUDr. Jana Čadová

Dermatol. praxi. 2020;14(2):81-84 | DOI: 10.36290/der.2020.014  

Hemangiomas are the most common skin tumor of childhood. Proper treatment requires proper diagnosis. Sometimes hemangiomas are confused with vascular malformations. Also, differentiation of some types of hemangiomas from other skin tumors may not always be clear. The article shows the practical approach to hemangiomas in dermatology or pediatrician offices and differential diagnosis.

Pitfalls of systemic and local corticosteroid treatment

prof. MUDr. Hana Matějovská Kubešová, CSc., MUDr. Ondřej Výška, MUDr. Jiří Nakládal, Jan Matějovský

Dermatol. praxi. 2020;14(2):85-90  

Corticosteroids were first used for therapeutic purposes in patients with rheumatoid arthritis and topically for relief in the case of skin exanthem. With increasing medical knowledge, the indications for their administration have been expanded to include a broad spectrum of clinical conditions. In an acute single-use setting, there is no contraindication to the administration of corticosteroids which can often be life-saving. With long-term treatment, one has to take into consideration the possible risks of adverse side effects resulting from the nature of corticosteroids as agents that provide coping with stress situations, thus increasing blood...

Gastroenteritis in a female patient with Harlequin ichthyosis

MUDr. Blanka Pinková, Mgr. Romana Borská, doc. RNDr. Lenka Fajkusová, MUDr. Dana Dostálková, MUDr. Hana Bučková, Ph.D.

Dermatol. praxi. 2020;14(2):96-98 | DOI: 10.36290/der.2020.017  

Hereditary ichthyoses are among rare diseases. They are a very heterogeneous group of diseases manifested by dry, rough, and scaly skin. In all forms of ichthyoses, there is an impairment of the skin barrier to a varying degree. Congenital ichthyoses are caused by various gene mutations. Clinical manifestations of the individual types of ichthyoses change with the patient's age. Harlequin ichthyosis is one of the most severe types of the disease. The authors describe unexpected complications resulting from an alimentary error that ultimately led to severe hepatopathy which required treatment in a specialized centre.

Guselkumkab in the treatment of severe form of psoriasis in polymorbid patient

MUDr. Jan Šternberský, Ph.D., MUDr. Martin Tichý, Ph.D.

Dermatol. praxi. 2020;14(2):99-102 | DOI: 10.36290/der.2020.018  

Guselkumab is one of the newest biologic drugs aimed for the treatment of psoriasis. It is fully humanized antibody against interleukin 23, which is the key initiating cytokin in the pathogenesis of psoriasis. Guselkumab has got excellent therapeutic response with longterm effect not only in clinical trials, but also in the real clinical practice. Up to date safety data are also very favorable. The case report describes excellent effect of guselkumab in the treatment of severe form of psoriasis in polymorbid patient.

Risankizumab (Skyrizi)

MUDr. Jiří Horažďovský, Ph.D.

Dermatol. praxi. 2020;14(2):91-95 | DOI: 10.36290/der.2020.016  

Imunopatogenetic mechanisms of psoriasis extend our possibilities for new targeting therapy. The crucial importance of interleukin 23 (IL-23) was recognized. Risankizumab is the next biologic drug with target inhibition of IL-23. Article summarizes the therapeuric potential of this drug and gives the first clinical experiences by myself.

Atypical lipomatous tumor (well -differentiated liposarcoma)

MUDr. Lubomír Drlík, doc. MUDr. Lumír Pock, CSc.

Dermatol. praxi. 2020;14(2):103-104 | DOI: 10.36290/der.2020.019  

Liposarcomas are the second most frequent tumors of soft tissues in adults after malignant fibrous histiocyoma. Well-differentiated liposarcomas (atypical lipomatous tumors) presents largest subgroup of liposarcoma (40-45%) accounts. It commonly arise in extremities and retroperitoneum. Recurrence rate is 30% and is not know to metastasize.

News in extemporaneous compounding in dermatology

PharmDr. Jan Hašek

Dermatol. praxi. 2020;14(2):105-108  

The article provides a pharmacist's insight into the options of external treatment of skin infections using extemporaneous preparations. Selected formulations from the groups of antiseptic, antibiotic, and antifungal drugs are presented that have emerged in the recent years or that are only being introduced into the practice. Therefore, emphasis is placed on the correct concentration of active substances and their compatibility with other compounds and vehicles for the preparation to be stable and have the desired efficacy.

Treatment of child patient with atopic dermatitis using topical imunomodulator

MUDr. Jana Kopuletá, MUDr. Blanka Pinková

Dermatol. praxi. 2020;14(2):109-110  

Case report describes 7 years old patient with atopic dermatitis, who was successfully treated with product Protopic ung. 0,03%.