Sdělování špatné zprávy (1. část)

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2022;16(4):187  

The News in a Treatment of Severe Forms of Acne

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2022;16(4):190-194 | DOI: 10.36290/der.2022.038  

In the first part of the article, a term severe acne is identified. Acne fulminans and acne fulminans sine fulminans are described in detail. There exist a recommendation for a treatment of severe forms od acne from 2016, peroral isotretinoin is a primary medicine in a treatment. This fact is valid till now but some recommendations for a treatment with this medicine have changed. There are especially a daily recommended dose (lower doses are prefered now), a length of a treatment (not a total cumulative dose but a length of a treatment after patient´s healing is important ) and a possibility of prevention of isotretinoin induced acne fulminans. Later,...

The present and future of enzybiotics in the therapy of infectious complications in the burned area caused by Staphylococcus aureus strains

MUDr. Filip Raška, doc. MUDr. Břetislav Lipový, Ph.D., MBA, LL.M., Mgr. Šárka Kobzová, Mgr. Lukáš Vacek, RNDr. Lubomír Janda, Ph.D.

Dermatol. praxi. 2022;16(4):195-198 | DOI: 10.36290/der.2022.039  

Even today, infectious complications in patients with thermal injury represent a complex issue, which significantly increases the morbidity and mortality of severely burned patients. Colonization and infection in the burned area are most often caused by various strains of Staphylococcus aureus. Due to the strong selection pressure of topically or systemically administered antimicrobial preparations, several multiresistant variants have developed over time in this pathogen. This fact leads to efforts to find other effective preparations in the fight against pathogenic microorganisms. One of the most promising possibilities appears to be the use...

Diagnosis of autoimmune bullous diseases

prof. MUDr. Hana Jedličková, Ph.D.

Dermatol. praxi. 2022;16(4):199-203 | DOI: 10.36290/der.2022.040  

Autoimmune blistering diseases are rare organ-specific autoimmune diseases characterized by autoantibodies against desmosomal and hemidesmosomal adhesive proteins of epidermis. They can be divided into two main groups - pemphigus group with intraepidermal blisters and pemphigoid group with subepidermal blisters. Correct diagnosis of the subtypes is based on a complex of clinical observation, histopatological and immunofluorescence examinations, detection of circulating autoantibodies by indirect immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and immunoblotting, thus allowing the precise diagnosis and the choice of appropriate therapy.

Adverse effects of systemically administered drugs on the skin

doc. MUDr. Karel Ettler, CSc.

Dermatol. praxi. 2022;16(4):205-210 | DOI: 10.36290/der.2022.041  

Adverse effects of systemic therapy can also be observed on the skin. Pharmacological (predictable) and idiosyncratic (unpredictable) responses are distinguished. Drug allergy is also included here, most often type IV (e. g., toxic epidermal necrolysis). The temporal relationship between an adverse reaction and drug intake is important for establishing the diagnosis; laboratory tests and in-vivo exposure tests are used for confirmation. Treatment measures primarily include discontinuing the suspected medication. In addition, topical dermatological treatment and, in more severe cases, systemic therapy can be provided (antihistamines, corticoids, and/or...

Oily skin and acne – what to recommend in a pharmacy?

PharmDr. Miroslava Pavelková, Ph.D.

Dermatol. praxi. 2022;16(4):212-216  

There is with acne a primarily oily type of skin. The recommended approach to oily skin and acne therefore overlaps. A common feature is targeting key factors (sebum overproduction, follicular hyperkeratinization, increased colonization of Cutibacterium acnes, and inflammation) that contribute to varying degrees in the acne´s pathogenesis. The role of professional staff at a pharmacy is to recommend how to properly care for oily/acne-prone skin and to advise in a selection of an appropriate (cosmetic) product, which must be irritant-free and without comedogenic substances.

Medical cannabis and its potential use in dermatology

PharmDr. Jaroslav Peč, Ph.D., Mgr. Dominika Kaczorová, Mgr. Tibor Béres, Ph.D., doc. RNDr. Petr Tarkowski, Ph.D., PharmDr. Jaroslav Matal, Ph.D.

Dermatol. praxi. 2022;16(4):217-220  

Cannabis for medical use has been successfully incorporated into Czech clinical practice, especially in the fields of algesiology and neurology. Under the current legislation, medical cannabis can also be used in dermatology in the indication surface treatment of dermatoses and mucosal lesions. However, this use is so far neglected, mainly due to the lack of a standardized procedure for the preparation of dermal dosage forms in pharmacies and also due to the unavailability of standardized medicinal cannabis extracts, which are available abroad. However, influencing the endocannabinoid system topically at the skin level provides an interesting pharmacological...

Genital lymphedema

MUDr. Naděžda Vojáčková

Dermatol. praxi. 2022;16(4):221-224 | DOI: 10.36290/der.2022.044  

genital lymphedema is a rare condition but it substantially impairs quality of life. Isolated genital lymphedema can occur, frequently it is together with lymphedema of the lower extremities. Genital lymphedema is classified as primary or secondary disorder. The investigation includes history, blood tests, venereology testing, lymphoscintigraphy, X-ray of the lungs, MRI, colonoscopy, skin biopsy. The therapy is a conservative, surgical or combined therapy. The conservative therapy is the complex decongesive therapy which is more diffucult due to the localisation. The most common surgical therapy is the resectional procedure of the abdomen wall, scrotum,...

Case of the Lyme disease in winter months

MUDr. Tereza Zedníčková, MUDr. Veronika Paťavová

Dermatol. praxi. 2022;16(4):225-227  

Lyme disease is the most common infectious disease transmitted by ticks in the Czech Republic. It is a zoonosis caused by spirochetes of the genus Borrelia. At greatest risk of disease are children between 5 to 9 years and adults over 55 years. Clinical skin manifestations of lyme disease are divided into three stages: Localised Lyme disease, Early disseminated Lyme disease, both a and Late Lyme disease, which occur months or years after infection. Lyme disease can also affect other part of the body like central nervous system, musculoskeletal system, heart, the eyes and other organs. 

Platelet-rich plasma and topical finasteride for androgenic alopecia: a case study

MUDr. Markéta Fridman, M.A.

Dermatol. praxi. 2022;16(4):228-230 | DOI: 10.36290/der.2022.046  

Androgenic alopecia is a common hair loss disorder caused by genetic and hormonal factors that are characterized by androgen-related progressive thinning of scalp hair in a defined pattern. First-line therapy for androgenic alopecia is topical minoxidil but due to its limited effect platelet-rich plasma (PRP) has become an effective alternative treatment. This case study presents a 35 year old male with androgenic alopecia treated with topical minoxidil for 3 years with minimal results. After 2 applications of PRP treatment with concomitant topical minoxidil and topical finasteride significant regrowth was seen within 3 months. This combined treatment...

Bimekizumab - new biological drug in the treatment of psoriasis

MUDr. Jan Šternberský, Ph.D., MUDr. Martin Tichý, Ph.D.

Dermatol. praxi. 2022;16(4):231-234 | DOI: 10.36290/der.2022.047  

In the therapy of psoriasis, we have a whole range of very effective biological drugs available on our market. Bimekizumab, an inhibitor of interleukin 17 (IL-17), is a new preparation that expands our options for the effective treatment of moderate to severe forms of chronic plaque psoriasis in adult patients. Bimekizumab has demonstrated its high effectiveness, rapid onset of action and favorable safety profile in a number of clinical studies.

Některé poznatky z 28. Fortbildungswoche für praktische Dermatologie und Venerologie 2022 (FOBI) - 13.-16. 7. 2022

doc. MUDr. Karel Ettler, CSc.

Dermatol. praxi. 2022;16(4):235-236  

Zpráva z 16. konference akné a obličejové dermatózy

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2022;16(4):237-238