Proč mizí z medicíny laskavost?

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2024;18(4):169

Side effects of methotrexate at low doses

MUDr. Alena Stumpfová

Dermatol. praxi. 2024;18(4):172-176 | DOI: 10.36290/der.2024.034

Methotrexate (MTX) is a folic acid antagonist with a broad spectrum of use in the treatment of (haemato)oncological, dermatological, rheumatological and other autoimmune diseases (E, B). Since 1971, it has been approved in the treatment of severe and generalized forms of psoriasis, and has also found its utilization in the treatment of other chronic skin diseases. Although it is a very effective drug and, given its variability of use, unique, its numerous adverse effects (AEs) are also known. Due to the lack of specific markers of MTX toxicity, their occurrence cannot be predicted. However, it is safe and well tolerated if certain dosing and treatment...

Primary cutaneous T-cell lymphomas - new therapeutical options

MUDr. Petra Fialová

Dermatol. praxi. 2024;18(4):178-184 | DOI: 10.36290/der.2024.035

Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma (CTCL). Sézary syndrome (SS) is a rare leukemic variant of CTCL. MF has a long course and is not easy to diagnose in the initial stages of the disease. Diagnosis at an early stage and initiation of therapy will increase the likelihood of achieving and maintaining a long-term disease free interval. Both in the treatment of MF and for patients with SS, we now have new therapeutic options that may prolong their overall survival.

Homeopathic treatment of childhood exanthematous diseases by a general paediatrician

MUDr. Martina Skařupová Kubicová

Dermatol. praxi. 2024;18(4):186-189 | DOI: 10.36290/der.2024.036

Every year in the spring months, general paediatricians encounter an increased number of exanthematous infectious diseases, particularly the fifth disease and sixth disease and chickenpox. The treatment of these diseases is only symptomatic in the vast majority of cases. In children with typical manifestations of these diseases, I supplement the classic treatment with homeopathics which are beneficial for the immune system and a more rapid recovery.

Advances in burn scar treatment: a comprehensive review of surgical and non-surgical interventions

MUDr. Júlia Bartková, MBA, MPH, MUDr. Gabriela Bakšová, Katarína Kentošová, Lívia Petrásšková

Dermatol. praxi. 2024;18(4):190-194 | DOI: 10.36290/der.2024.037

Burn injuries often result in long-term sequelae, including the formation of scars, which can significantly impact patients' physical and psychological well-being. Managing burn scars is a complex endeavor that requires a comprehensive approach encompassing both surgical and non-surgical interventions. Surgical techniques such as excision, grafting, and tissue expansion play a role in scar management, and aim to optimize function and cosmetic result. However, non-surgical modalities such as pressure garments, silicone-based products, laser therapy, and topical agents also have a vital role in scar reduction and remodeling. This article provides an...

Erosive pustular dermatosis of the scalp in a 32 year old female patient

MUDr. Nadezhda Vidolova Brabcová

Dermatol. praxi. 2024;18(4):196-197 | DOI: 10.36290/der.2024.038

Erosive pustular dermatosis of the scalp (EPDS) is a rare chronic inflammatory disease. It is characterized by extensive pustular lesions, erosions and crusts located on the scalp. It usually affects the elderly but can also affect people of different ages. In this case report, I describe the case of a young 32-year-old female patient with EPDS.

ORF - rare viral disease

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2024;18(4):198-201 | DOI: 10.36290/der.2024.039

A casuistics of 41-old man, who came to our out-patient department because of typical manifestation of orf infection on a finger of his left hand is presented. In addition, multiforme exanthema on his body was present. A local therapy of orf with a disinfecting agens under plaster was given. Multiforme exanthema was treated by peroral antihistamine agent and local corticosteroid. A patient was healed within 15 days. A presence of orf virus was confirmed by PCR examination from a swab. A source of infection were most probable patient´s sheeps. An aetiology, clinical picture, diagnosis, differential diagnosis, complications and treatment of orf virus...

Dupilumab and prurigo nodularis in hepatopathy

MUDr. Eva Březinová, Ph.D.

Dermatol. praxi. 2024;18(4):202-205 | DOI: 10.36290/der.2024.040

The case report describes a 67-year-old female patient with long-lasting severe prurigo nodularis, which arose in association with hepatopathy. Due to this comorbidity, the options for systemic therapy were limited. Dupilumab proved to be an effective and safe treatment in this patient. The effect of dupilumab on liver metabolism and regeneration has not yet been fully investigated. In practice, however, there are no recorded cases of liver function deterioration or even liver failure following this drug.

The itchy hump in child's scalp

MUDr. Diana Maxianová

Dermatol. praxi. 2024;18(4):206-208 | DOI: 10.36290/der.2024.041

The case report describes a case of a deep form of dermatophytosis in child's hair, otherwise called kerion Celsi, emphasing a fast diagnosing and early use of peroral antimycotic treatment as a prevention of persistent hair loss.

Suppurating lesion on the scalp

MUDr. Jan Finsterle, MUDr. Kateřina Gregorová, prof. MUDr. Spyridon Gkalpakiotis, Ph.D., MBA

Dermatol. praxi. 2024;18(4):209-212 | DOI: 10.36290/der.2024.042

Tinea capitis is a dermatophytic infection affecting the scalp, most commonly in children. This infection is caused by anthropophilic or zoophilic dermatophytes, with zoophilic species often leading to severe inflammatory forms, such as kerion Celsi. Kerion Celsi presents as painful nodules and abscesses on the scalp, often accompanied by secondary bacterial infections. Diagnosis is based on mycological examination. Treatment includes systemic antifungals, such as terbinafine or itraconazole, and topical therapy, with an emphasis on accurate diagnosis and timely treatment to prevent complications like scarring alopecia. Prevention involves hygiene...