Dermatol. praxi. 2025;19(3):108-112 | DOI: 10.36290/der.2025.020

Urticaria as a manifestation of Alpha-gal syndrome

MUDr. Tomáš Balner, doc. MUDr. Jaromír Bystroň, CSc.

Oddělení alergologie a klinické imunologie FN Ostrava, Ústav laboratorní medicíny, Lékařská fakulta, Ostravská univerzita v Ostravě

Chronic urticaria (CU) is a common and serious mast cell-mediated dermatological condition characterized by the development of pruritic wheals, angioedema, or both manifestations persisting for more than six weeks. The disease affects approximately 0,5-1% of the global population and significantly impairs patients' quality of life while generating substantial healthcare costs. Unlike acute urticaria, which typically resolves within six weeks, chronic urticaria presents specific diagnostic and therapeutic challenges requiring comprehensive understanding of its pathophysiology, classification, and management. The presented case report of alpha-gal syndrome emphasizes the importance of periodic reassessment of patients with long-standing "spontaneous" urticaria, as even apparently idiopathic cases may have an identifiable and treatable underlying cause.

Keywords: chronic urticaria, angioedema, alpha-gal syndrome, allergy.

Accepted: September 23, 2025; Published: October 2, 2025  Show citation