Jak se dívat na psychosomatiku

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2015;9(3)  

Ustekinumab in treating psoriatic arthritis

MUDr.Hana Ciferská, Ph.D., MUDr.Jiří Štolfa

Dermatol. praxi. 2015;9(3):99-103  

Ustekinumab is a fully human IgG1κ monoclonal antibody that inhibits interleukin 12 and 23 functions by binding to their p40 subunit. Ustekinumab is used in treating moderate and severe form of dermal psoriasis; however, a number of clinical studies have shown its effect on extradermal manifestations, particularly on the musculoskeletal system. PSUMMIT-1 and -2 clinical studies in patients with psoriatic arthritis have demonstrated good properties of ustekinumab for inducing a rapid therapeutic response with a good safety profile, and allowed registration for this indication as well.

Atopic dermatitis - theory and practical guidelines

MUDr.Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2015;9(3):104-110  

Atopic dermatitis is a very common disease. Most commonly it affects sucklings and young children. In the article, epidemiology, ethiopathogenesis, clinical picture and treatment of atopic dermatitis are described. It is put the stress on the fact, that even the most effective medicines cannot eliminate a hereditary disposition to the disease because this lasts for the whole life. However, it is possible by a careful observation of preventive and therapeutic arrangements to heal disease signs and so to get eczema´s course under control. The far-reaching management of atopic dermatitis is based on the prevention methods, regular individualized care...

Aetiopathogenesis and treatment of acne vulgaris

MUDr.Iva Obstová

Dermatol. praxi. 2015;9(3):111-115  

This article reviews the pathogenesis, clinical picture, and options of topical and systemic treatment of acne vulgaris. Also presented are the methods of corrective dermatology.

Onychomycosis

MUDr.Zuzana Kulíková

Dermatol. praxi. 2015;9(3):116-118  

Onychomycosis is a mycotic infection of a nail apparatus by microscopic fungi. Clinical presentation is discoloration, hyperkeratosis and detachment of nail plate from the nail. The disease could cause serious complication in immunocompromised patients. The main diagnostic methods are KOH preparation, fungal cultivation and eventually histology. Systematic therapy is still the most effective therapy in combination with debridement. Recently laser therapy is used in some clinics. One of the possible approaches could be photodynamic therapy, which is not used yet and other studies are needed.

Current trends in treating atopic dermatitis

MUDr.Miroslav Kobsa, MBA, MUDr.Zenon Lasota

Dermatol. praxi. 2015;9(3):120-123  

The authors summarize the current treatment options for atopic dermatitis, particularly taking into consideration the overall strategy and some new options in treating torpid forms of this disease.

Recent findings of immunogenetics in relation to the development of serious drug-induced skin reactions

MUDr.Břetislav Lipový, Ph.D.

Dermatol. praxi. 2015;9(3):124-127  

Toxická epidermální nekrolýza (TEN) a Stevens-Johnsonův syndrom (SJS) patří do širší skupiny závažných polékových kožních reakcí (SCARs – Severe cutaneous adverse reactions). Do této skupiny patří také DRESS (Drug reaction with eosinophilia and systemic symptoms) a DIHS (Drug induced hypersenzitivity syndrome). V průběhu posledního desetiletí dochází k progresi povědomí o patofyziologické povaze jednotlivých syndromů a mechanizmů účinku léků, které k rozvoji těchto stavů vedou. Díky případům nakupení těchto stavů u příbuzných pacientů se došlo k názoru, že za řadou SCARs může být genetická predispozice (zejména v oblasti hlavního histokopatibilního...

Baby’s skin care

MUDr.Michaela Syrovátková

Dermatol. praxi. 2015;9(3):128-129  

The article discusses the specifics of baby’s skin care, depending on the age of the child. Summarizes how timely prevent damage. The aim of skin care is to protect it from the effects of negative external environment, to maintain optimal hydration to prevent overheating or drying.

Serious form of rosacea in 32 years old patient

MUDr.Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2015;9(3):130-133  

The case of a 32 years old patient with an erythematoteleangiectatic and a papulopustulous forms of rosacea accompanied with serious ocular problems is reported. Skin problems were present for 1,5 year. In the beginning of problems the patient herself used local corticoid for 3 months. Following treatment with local metronidazol was without any effect. The patient had no therapy in the last 6 months. Because of suspicion of rheumatoid arthritis she used peroral corticoids for 2 months, above mentioned diagnosis was not validated. A therapy with peroral antibiotic doxybene was administered, local metronidazol cream was applied. Skin troubles...

Porphyria cutanea tarda

MUDr.Hana Mičaníková

Dermatol. praxi. 2015;9(3):134-136  

Porphyria cutanea tarda is often neglected in the differential diagnosis despite of its frequent occurrence. Untreated porphyria cutanea tarda can lead to serious complications in form of a hepatic lesion up to the hepatocellular carcinoma. Purpose of this article is to remind of the issue of this pathological unit, especially its diagnostic algorithm and therapy with a description of the typical case.

Pharmaceutical care of the scalp disease such as dandruff, seborrheic dermatitis and psoriasis

Mgr.Jana Martinásková

Dermatol. praxi. 2015;9(3):137-140  

with localization on the scalp This article reviews the OTC products and recommendations for the proper care of the scalp disease such as dandruff, seborrheic dermatitis and psoriasis with localization on the scalp. Each of these diseases in varying degrees affects the quality of life of patients. To minimize bothersome symptoms and reduce the frequency of relapses is preventive care by using the OTC dermocosmetics available in pharmacies important.

Primary cutaneous lymphomas: basic classification and characteristics

MUDr.Eliška Langerová

Dermatol. praxi. 2015;9(3):141-142  

Cutaneous T-, NK- and B-cell lymphomas are primary cutaneous non-Hodgkin lymphomas. It is a group of heterogeneous diseases; therefore, the classification of this group of skin diseases is crucial in diagnosing and, subsequently, treating them. The first comprehensive classification system was developed in a collaborative effort between the WHO (World Health Organization) and the EORTC (European Organisation for Research and Treatment of Cancer) in the year 2005. The article is focused on the classification of cutaneous lymphomas and is the first in a series of articles dealing with this issue. The individual diagnoses will be described in...