Proč přibývá stresu?

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2022;16(3):123  

Melkersson-Rosenthal syndrome in clinical practice

MUDr. Andrea Jelínková, MUDr. Gvantsa Kharaishvili

Dermatol. praxi. 2022;16(3):127-129 | DOI: 10.36290/der.2022.024  

Melkersson-Rosenthal syndrome is a rare disorder of unknown etiology characterized by a group of symptoms that most commonly include orofacial edema, facial nerve palsy, and tongue wrinkling. At least two of the above symptoms are necessary for a clinical diagnosis. Corticosteroids are the mainstay of treatment. The following report describes the clinical case of a 51-year-old woman with chronic swelling of the lower lip and the treatment options for Melkersson-Rosenthal syndrome.

Treatment of spinalioma in clinical practice

MUDr. Ondřej Kodet

Dermatol. praxi. 2022;16(3):130-134 | DOI: 10.36290/der.2022.025  

Cutaneous squamous cell carcinoma (spinalioma) is one of the most common cancers. Its incidence is constantly increasing and thus represents a significant health socio-economic problem. The basic of treatment is radical surgical excision with a sufficient margin of healthy tissue, of the non-surgical options, the method of choice is radiotherapy. The introduction of immunotherapy into the treatment of metastatic and locally advanced cutaneous spinalioma brought significant improvements in the care of these patients, was essential. The dermatologist struggles with the diagnosis of spinalioma in current clinical practice, and its necessary to control...

Pyoderma gangraenosum induced by surgery

MUDr. Veronika Šopíková, MUDr. Jan Šternberský, Ph.D.

Dermatol. praxi. 2022;16(3):135-138 | DOI: 10.36290/der.2022.026  

Pyoderma gangraenosum is a rare non-infectious inflammatory dermatosis, conditioned by a pathological immune response of the organism, manifested by the formation of painful, rapidly progressing ulcerations with a characteristic appearance. A rare variant is postoperative pyoderma gangraenosum arising in surgical incisions as a pathogenic reaction to skin trauma. The report describes a clinical case of a patient with pyoderma gangraenosum manifesting at the site of an established drain after surgery for left lung adenocarcinoma.

Primary vasculitides in dermatological practice

doc. MUDr. Radim Bečvář, CSc.

Dermatol. praxi. 2022;16(3):139-144 | DOI: 10.36290/der.2022.027  

By term "vasculitis" inflammatory disease of blood vessels is designated that leads to vessel wall destruction followed by proliferation and occlusion of their lumina. Basic condition for this diagnosis is that vessel wall is a primary site of the pathological process. Clinical syndromes are a consequence of this process resulting into ischaemia of tissues supplied by the affected vessels and with constitutional symptoms associated to the inflammatory disease. Vasculitis can occur de novo as a primary involvement of vessel wall of unknown aetiology or it develops secondary to other diseases. The diagnosis of vasculitis is usually based on pathological...

Ageing woman at dermatology

doc. MUDr. Tomáš Fait, Ph.D.

Dermatol. praxi. 2022;16(3):145-149 | DOI: 10.36290/der.2022.028  

Menopause is conected and based on hard fall of the estrogen selfproduction. It induce negative changes in skin. Protective effects of any systemic estrogene therapy is clear and evidence-based. Hormone replacement therapy´s indication is temporary, it is why role of special cosmetics for ageing skin could not be ignore.

Rigid nodules in the umbilical region

MUDr. Irina Afanasyeva, doc. MUDr. Spyridon Gkalpakiotis, Ph.D., MBA, MUDr. Václav Eis, Ph.D., MUDr. Jan Hugo

Dermatol. praxi. 2022;16(3):150-152 | DOI: 10.36290/der.2022.029  

This case report describes a 65-year-old man with new lesions in the umbilical region. Based on histopathological examination, it was found to be "Sister Mary Joseph's nodules", metastases of poorly differentiated pancreatic cancer.

Severe form of atopic dermatitis in a boy with liver transplant and two subsequent retransplantions

MUDr. Štěpánka Čapková

Dermatol. praxi. 2022;16(3):153-156 | DOI: 10.36290/der.2022.030  

There is a lack of literature regarding the treatment of atopic dermatitis (AD) in patients with organ transplants. Despite the immunosuppressive regiments in the post-transplant population, de novo development of AD is well- documented phenomenon, particularly in liver transplant recipients. We report a case of dupilumab treatment in a liver transplant adolescent with severe AD under immunosuppressive therapy with tacrolimus.

An unussual type of bullous disease

MUDr. Eva Valihrachová

Dermatol. praxi. 2022;16(3):157-159 | DOI: 10.36290/der.2022.031  

Next case report describes 57 year old patient with personal history of lichen ruber planus, who suddenly developed bullous diseae.

Lymphoepithelioma-like carcinoma of the skin

MUDr. Ľudmila Michnová, MUDr. Eva Traboulsi

Dermatol. praxi. 2022;16(3):161-162 | DOI: 10.36290/der.2022.032  

Lymhoepithelioma-like carcinoma of the skin (LELCS) is an extremely rare tumor morphologically similar to undifferentiated nasopharyngeal carcinoma. The presence of this type of tumor has been described in skin areas exposed to the sun, more often in the elderly in the age of 70, manifests as a solitary nodule. LELCS has very good prognosis, most patients are cured by local excision.

Collagen and its use in dermatology

MUDr. Martina Matzenauer

Dermatol. praxi. 2022;16(3):171-174 | DOI: 10.36290/der.2022.035  

Aging is an inevitable process that none of us can avoid. With advancing age and mainly as a result of the times we live in, younger and younger groups of people are interested in improving their appearance and rejuvenation, especially in the facial area. Hand in hand with this interest goes the market, which offers a variety of support products and products that promise firmer, more flexible and, above all, more beautiful skin without wrinkles. Collagen in various forms, whether oral or in the form of creams, has enjoyed the greatest interest in recent years, thanks in no small part to the influence of advertising in the media and on social networks....

The Use of Topical JAK Inhibitors in Dermatology

MUDr. Petra Matalová, Ph.D., MUC. Karolína Šimková

Dermatol. praxi. 2022;16(3):164-166 | DOI: 10.36290/der.2022.033  

The JAK/STAT signaling pathway is activated by a number of cytokines and growth factors. Drugs known as JAK inhibitors (JAKi) target cytokine signalization by either oral or topical administration. Topical application can minimize the risk of side effects observed with systemic application. The following article discusses different skin diseases in which local JAKi have positive therapeutic effect. Their use also reduces the risk of side effects of immunosuppressants and local corticosteroids.

Current Role of 5-fluorouracil in the Treatment of Actinic Keratosis

doc. MUDr. Jiří Slíva, Ph.D.

Dermatol. praxi. 2022;16(3):167-170 | DOI: 10.36290/der.2022.034  

Actinic keratosis is the most common skin precancerosis that occurs on skin damaged by chronic exposure to ultraviolet radiation, hence the synonym "solar keratosis". The range of treatment options is relatively strict, but in addition to surgery and cryotherapy, it includes topical pharmacotherapy. The article summarizes the basic observations of the treatment options and focuses mainly on the benefits of 5-fluorouracil in 5% and the innovative 4% form of the cream.

Risankizumab v terapii psoriatické artritidy

MUDr. Eva Gavendová

Dermatol. praxi. 2022;16(3):175-176  

Chronická spontánní kopřivka jako autoimunitní onemocnění

MUDr. Iva Karlová

Dermatol. praxi. 2022;16(3):178-179  

Biologická léčba psoriázy - účinná metoda, o které většina pacientů neví

doc. MUDr. Spyridon Gkalpakiotis, Ph.D., MBA

Dermatol. praxi. 2022;16(3):180-182