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MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2026;20(2):51

Differential diagnosis and management of lower limb edema in dermatological practice

MUDr. Natálie Michalík, MUDr. Silvie Rafčíková, MBA

Dermatol. praxi. 2026;20(2):54-59 | DOI: 10.36290/der.2026.009

Lower limb edema represents a common clinical symptom with a wide number of etiologies, ranging from chronic venous insufficiency and lymphedema to systemic diseases or life-threatening diagnoses like deep vein thrombosis. For the dermatologist, correct differential diagnosis based on patient history, physical examination, and, in indicated cases, imaging modalities is crucial. This article presents a clear diagnostic algorithm and management of lower limb edema in routine dermatological practice and specifically focuses on the treatment of venous and lymphatic edema, which is based on lifestyle measures, compression therapy, venoactive drugs, and...

Trends in acne treatment in adolescents

MUDr. Anna Hrazdírová

Dermatol. praxi. 2026;20(2):60-64 | DOI: 10.36290/der.2026.010

Acne is one of the most common dermatological conditions of adolescence, significantly affecting the quality of life of patients. Current trends in treatment emphasize the early use of topical retinoids, the use of fixed-dose combinations, earlier initiation of oral isotretinoin, and the limited use of antibiotic therapy. Dermocosmetic care is an important part of the treatment as well. Minimally invasive aesthetic procedures are increasingly used in the management of acne sequelae, particularly scars and post-inflammatory pigmentation. The treatment should be individualized, simple, and targeted not only at active manifestations of the disease, but...

Non-melanoma skin cancers: part I. basal cell carcinoma and squamous cell carcinoma

MUDr. Edita Marvanová

Dermatol. praxi. 2026;20(2):65-73 | DOI: 10.36290/der.2026.011

Malignant skin tumors represent a heterogeneous group consisting of melanoma as a distinct entity and the so-called non-melanoma skin cancers (NMSC). This classification is based on the different biological behaviour of individual tumors, which determines distinct therapeutic approaches. The main representatives of NMSC are basal cell carcinoma (75-80 % of NMSC) and squamous cell carcinoma (20 % of NMSC). Less common skin malignancies include Kaposi sarcoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, extramammary Paget disease, and adnexal carcinomas. Cutaneous metastases from internal malignancies may also occur. The aim of this article...

Inhibitors of Bruton's tyrosine kinase in the treatment of chronic spontaneous urticaria

MUDr. Tomáš Balner

Dermatol. praxi. 2026;20(2):74-77 | DOI: 10.36290/der.2026.012

Chronic spontaneous urticaria (CSU) is a disease with a substantial impact on quality of life, and in a proportion of patients it remains inadequately controlled despite maximum‑dose second‑generation H1 antihistamines and treatment with omalizumab. The updated international CSU treatment algorithm includes remibrutinib, alongside omalizumab and dupilumab, as a second‑line add‑on therapy to second‑generation antihistamines. This article reviews the mechanism of action of BTK inhibitors, key clinical data on the new generation of Bruton's tyrosine kinase inhibitors, and practical aspects of their use (safety, vaccination,...

Food allergens and their relevance in dermatological practice

MUDr. Mojmír Račanský

Dermatol. praxi. 2026;20(2):78-80 | DOI: 10.36290/der.2026.013

Dietary allergens are a primary trigger for allergic and pseudoallergic reactions. The skin is among the most commonly affected organs, involved in early IgE-mediated responses as well as in non-IgE-mediated and mixed immunopathological mechanisms. The clinical manifestations include acute urticaria, angioedema, contact urticaria, flare-ups of atopic dermatitis, and chronic itching. In addition to naturally occurring food allergens, food additives and preservatives play a significant role, as they can cause pseudoallergic reactions - especially in patients with chronic urticaria. Diagnosis relies on a detailed medical history, targeted laboratory tests,...

Carcinoma en cuirasse: cutaneous metastases as a manifestation of breast cancer relapse

MUDr. Monika Baláž, MUDr. Martin Tichý, Ph.D., MUDr. Patrik Flodr, Ph.D.

Dermatol. praxi. 2026;20(2):81-83 | DOI: 10.36290/der.2026.014

Carcinoma en cuirasse is a rare form of cutaneous metastases, most commonly associated with breast cancer. It is clinically manifested as diffuse sclerodermiform induration of the skin. We present a case of a 68-year-old female patient with a history of triple-nega­tive breast cancer who developed a palpably firm lesion in the mastectomy scar site after more than three years of remission. Histopathological examination confirmed a metastatic process congruous with carcinoma en cuirasse. The case highlights the importance of early biopsy in newly developed induration in a mastectomy scar and the dermatologist's role in diagnosing local recurrence.

The fractional 1927-nm thulium laser as a treatment modality for actinic keratosis

MUDr. Kevin Machů

Dermatol. praxi. 2026;20(2):84-86 | DOI: 10.36290/der.2026.015

This paper presents a case report of a 45-year-old patient in whom multiple actinic keratoses of the scalp consistent with field cancerization were detected during a total body dermoscopic examination. At the same time, a nodular basal cell carcinoma on the right shoulder was identified. Considering the patient's preferences, treatment with a 1927 nm fractional thulium laser was chosen. The first session was well tolerated by the patient and led to a marked improvement in both clinical and dermoscopic findings. The article further discusses the use of the fractional thulium laser in the treatment of actinic keratoses and its role among other...

Kolodium forte a léčba virových bradavic: Výsledky postmarketingové, retrospektivní otevřené studie

Dr. Ing. Petr Behenský, Ing. Milada Bauerová, Mgr. Andrea Fialová

Dermatol. praxi. 2026;20(2):90-92

Self-medication of viral warts: options for keratolytic therapy with salicylic and lactic acids potentiated by herbal components

PharmDr. Bc. Hana Kotolová, Ph.D.

Dermatol. praxi. 2026;20(2):87-89 | DOI: 10.36290/der.2026.016

Common warts (verruca vulgaris) are a frequent benign viral skin disease caused by human papillomaviruses (HPV). In many cases, they are suitable for self-medication. The mainstay of home treatment consists of keratolytic preparations containing salicylic acid and lactic acid, most commonly formulated as collodion solutions. This article summarizes the mechanisms of action of these agents, the principles of the collodion dosage form, recommendations for proper application, the indications and limitations of self-treatment, and an overview of products available on the Czech market.

Význam včasné modifikace průběhu atopické dermatitidy cílenou terapií z pohledu snížení rizika rozvoje komorbidit

MUDr. Veronika Sommerlíková

Dermatol. praxi. 2026;20(2):93-94