Medicína musí udělat několik nepopulárních kroků, aby zůstala čistá a užitečná
1. Pojetí ČLOVĚKA ve zdraví a nemoci

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2019;13(4):163  

Hidradenitis suppurativa/acne inversa – diagnosis and management

MUDr. Eliška Langerová

Dermatol. praxi. 2019;13(4):168-173  

Hidradenitis suppurativa or acne inversa is a chronic, inflammatory, reccurent, debilitating skin disease that usually presents after puberty with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas of the body, most commonly the axillaries, inguinal and anogenital regions (Dessau definiton, 1st International Conference on Hidradenitis suppurativa, March 30-April1, 2006, Dessau, Germany). Hidradenitis suppurativa is very serious illness with certain complications and comorbidities and refractory results for the patients, but unfortunatelly it is still either lately or misdiagnosed. Prevalence is 1% of population. It starts after...

Skin care of the skin skin with atopy

MUDr. Helena Michalíková

Dermatol. praxi. 2019;13(4):174-176  

The first manifestation of atopy in early childhood is atopic dermatitis. Later, food allergies, allergic rhinitis and asthma may follow as part of the so-called atopic march. The impaired skin barrier function in the development of atopic dermatitis is the most important. Here, the decisive function of the topmost layer of the epidermis stratum corneum is crucial. In the care of atopic skin, it is necessary to identify factors that further worsen the condition of the skin barrier, eliminate them or at least minimize them. Cleansing the atopic skin requires the use of mild detergents and the subsequent hydration of the skin with an appropriate emoliant...

Difficult to treat psoriasis of scalp, nails, palms and soles

MUDr. Lucia Mansfeldová

Dermatol. praxi. 2019;13(4):178-182  

Psoriasis of scalp, nails, palms and soles belong to group called difficult to treat psoriasis. Incidence of these types of psoriasis is not as frequent as typical plaque psoriasis, but it means a big psychosocial impact on the patient. For patient it presents limitation at work and daily routine. Possibilities of treatment are mostly limited by its localization (barrier of hair, nail plate and strong hyperkeratosis of palms and soles), it is often resistant to therapy and shows frequent relapse. Systemic treatments are necessary in case the topical therapy is not successful considering the higher psychological impact on the patient. In this article...

Summary of our experiences with treatment of chronic spontaneus urticaria with omalizumab

MUDr. Iva Karlová

Dermatol. praxi. 2019;13(4):184-186  

Biological treatment with monoclonal anti IgE antibody omalizumab is recommended for chronic spontaneus urticaria providedall indication kriteria are met.Chronic spontaneous urticaria is disease characterized by recurrent pomphus or angioedema for more than 6 weeks. Pomphusappears daily od almost daily on different parts of the body. Individual manifestations disappear within 24 hours. The durationof angioedema may be longer –up to 72 hours

Biological therapy of atopic dermatitis

MUDr. Nina Benáková, Ph.D.

Dermatol. praxi. 2019;13(4):187-189  

In dermatology in Czech Republic there are biologicals for treatment of psoriasis, chronic urticaria and melanoma available,and now also for treatment of atopic dermatitis- the first one is dupilumab. The introduction of biologicals into the treatment ofatopic dermatitis indicates the further release of new drug groups. The positive side effect is the revision of the existing drugs,especially ciclosporine A and methotrexate. This together could lead to treatment of more patiens with severe atopic dermatitisthan yet – the relative undertreament is a worldwide fact.

Malignant melanoma imitating deep mycosis

MUDr. Viktor Palla, MUDr. Martin Tichý, Ph.D., doc. MUDr. Světlana Brychtová, Ph.D.

Dermatol. praxi. 2019;13(4):190-194  

In this document, there is represented a case of 73-year-old man who was referred to our department by a outpatient dermatologistdue to a month-lasting ulcerated lesion in hair. With regarding to the clinical picture and anamnestic data about horsebreeding a deep mycosis of Kerion Celsi character was considered in the differential diagnosis. Nonetheless, skin biopsy hasproven extremely advanced nodular melanoma.

Psoriasis in difficult‑to‑treat areas – successful treatment with secukinumab

MUDr. Jan Hugo, doc. MUDr. Spyridon Gkalpakiotis, Ph.D., MBA

Dermatol. praxi. 2019;13(4):195-197  

Psoriasis exhibits particularly high resistance to topical and sometimes even systemic therapy in some specific locations. Althoughthe affected area is not vast, there is often a dramatic decrease in the quality of life of patients. The case report refers a patientwith several such localizations where the success of treatment was only achieved with biological therapy with secukinumab.

Preliminary results of a research survey on non-healing wound assessment

PhDr. Adéla Holubová

Dermatol. praxi. 2019;13(4):207-210  

Currently, non-healing wounds are a major socioeconomic problem, and the care of patients with a non-healing wound is a complex interdisciplinary issue, since it is derived from a multidisciplinary focus. In the clinical practice, the process of non-healing wound assessment is still very problematic and inconsistent. The present research was aimed at the issue of documentation of non-healing wounds in the clinical practice in selected inpatient health facilities in the Czech Republic. The goal of the research is to assess and evaluate the methods for non-healing wound assessment in the clinical practice in selected inpatient and outpatient facilities...

Use Profhilo to slow down the appearance of aging skin

MUDr. Dominika Diamantová, Ph.D.

Dermatol. praxi. 2019;13(4):203-206  

The process of skin aging is a physiological process. Nowadays, more and more emphasis is placed on the aesthetic appearanceof the face and body. One way to slow down skin aging is to use the Profhilo medical device. The product can beused to remodel flabby skin in the face, neck and body. A special technique for application of Profhilo to the skin has alsobeen developed.

Starosta s progredující psoriázou

MUDr. Jitka Bočková

Dermatol. praxi. 2019;13(4):213-214  

Risankizumab (Skyrizi)

MUDr. Petra Fialová

Dermatol. praxi. 2019;13(4):198-202  

Psoriasis is a chronic inflammatory disease with systemic impact. Ongoing research of psoriasis pathogenesis has brought distinct changes concerning possible treatment methods over the past 20 years. Identification of the essential role of interleukin 23 (IL–23) as the main regulatory cytokine and confirmation of the importance of interleukin 23/Th lymphocytes 17 (IL–23/Th17) passway are considered to be the latest breakthrough in psoriasis research and new molecules development. Being the IL-23 inhibitor, Risankizumab is the latest biologic therapy which was registered for treatment of moderate to severe plaque psoriasis in adult patients...